Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues.

Autor:	Spang MT; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Middleton R; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Diaz M; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Hunter J; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Mesfin J; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Banka A; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA., Sullivan H; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Wang R; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Lazerson TS; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Bhatia S; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Corbitt J; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., D'Elia G; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Sandoval-Gomez G; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Kandell R; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Vratsanos MA; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA., Gnanasekaran K; Department of Chemistry, International Institute for Nanotechnology, Chemistry of Life Processes Institute, Simpson Querrey Institute, Northwestern University, Evanston, IL, USA., Kato T; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Igata S; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Luo C; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Osborn KG; Animal Care Program, University of California San Diego, La Jolla, CA, USA., Gianneschi NC; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.; Department of Chemistry, International Institute for Nanotechnology, Chemistry of Life Processes Institute, Simpson Querrey Institute, Northwestern University, Evanston, IL, USA.; Department of Biomedical Engineering and Department of Pharmacology, Northwestern University, Evanston, IL, USA., Eniola-Adefeso O; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Cabrales P; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Kwon EJ; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Contijoch F; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.; Department of Radiology, University of California San Diego, La Jolla, CA, USA., Reeves RR; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., DeMaria AN; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Christman KL; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. christman@eng.ucsd.edu.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA. christman@eng.ucsd.edu.
Jazyk:	angličtina
Zdroj:	Nature biomedical engineering [Nat Biomed Eng] 2023 Feb; Vol. 7 (2), pp. 94-109. Date of Electronic Publication: 2022 Dec 29.
DOI:	10.1038/s41551-022-00964-5
Abstrakt:	Decellularized extracellular matrix in the form of patches and locally injected hydrogels has long been used as therapies in animal models of disease. Here we report the safety and feasibility of an intravascularly infused extracellular matrix as a biomaterial for the repair of tissue in animal models of acute myocardial infarction, traumatic brain injury and pulmonary arterial hypertension. The biomaterial consists of decellularized, enzymatically digested and fractionated ventricular myocardium, localizes to injured tissues by binding to leaky microvasculature, and is largely degraded in about 3 d. In rats and pigs with induced acute myocardial infarction followed by intracoronary infusion of the biomaterial, we observed substantially reduced left ventricular volumes and improved wall-motion scores, as well as differential expression of genes associated with tissue repair and inflammation. Delivering pro-healing extracellular matrix by intravascular infusion post injury may provide translational advantages for the healing of inflamed tissues 'from the inside out'. (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze:	MEDLINE
Externí odkaz:	Full text from SpringerLink