Premotor, nonmotor and motor symptoms of Parkinson's Disease: A new clinical state of the art.

Autor: Leite Silva ABR; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Gonçalves de Oliveira RW; Faculdade Metropolitana de Manaus, FAMETRO, Manaus, AM, Brazil., Diógenes GP; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., de Castro Aguiar MF; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Sallem CC; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Lima MPP; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., de Albuquerque Filho LB; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Peixoto de Medeiros SD; Universidade Estácio de Sá - UNESA, Rio de Janeiro, RJ, Brazil., Penido de Mendonça LL; Centro Universitário Facisa, UNIFACISA, Campina Grande, Paraíba, Brazil., de Santiago Filho PC; Faculdade de Medicina, Universidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil., Nones DP; Neurologista. Hospital São Vicente de Paulo, Mafra, SC, Brazil., da Silva Cardoso PMM; Universidade Federal da Paraíba, UFPB, João Pessoa, Paraíba, Brazil., Ribas MZ; Universidade Federal do Paraná, UFPR, Curitiba, Paraná, Brazil., Galvão SL; Centro Universitário Barão de Mauá, CUBM, Ribeirão Preto, São Paulo, Brazil., Gomes GF; Centro Universitário Barão de Mauá, CUBM, Ribeirão Preto, São Paulo, Brazil., Bezerra de Menezes AR; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Dos Santos NL; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Mororó VM; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Duarte FS; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil., Dos Santos JCC; Centro Universitário Christus, UNICHRISTUS, Fortaleza, CE, Brazil; Universidade Federal do Ceará, Fortaleza, CE, Brazil; Programa de Pós-graduação em Ciências Morfofuncionais, Departamento de Morfologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address: julio.santos@alu.ufc.br.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2023 Feb; Vol. 84, pp. 101834. Date of Electronic Publication: 2022 Dec 26.
DOI: 10.1016/j.arr.2022.101834
Abstrakt: Parkinson's Disease (PD) is a neurodegenerative disorder that affects dopaminergic neurons in the mesencephalic substantia nigra, causing a progressive clinical course characterized by pre-motor, non-motor and motor symptoms, which negatively impact the quality of life of patients and cause high health care costs. Therefore, the present study aims to discuss the clinical manifestations of PD and to make a correlation with the gut-brain (GB) axis, approaching epidemiology and therapeutic perspectives, to better understand its clinical progression and identify symptoms early. A literature review was performed regarding the association between clinical progression, the gut-brain axis, epidemiology, and therapeutic perspectives, in addition to detailing pre-motor, non-motor symptoms (neuropsychiatric, cognitive, autonomic, sleep disorders, sensory abnormalities) and cardinal motor symptoms. Therefore, this article addresses a topic of extreme relevance, since the previously mentioned clinical manifestations (pre-motor and non-motor) can often act as prodromal markers for the early diagnosis of PD and may precede it by up to 20 years.
Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest. All authors read and approved the final manuscript.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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