The Role of Claudin-1 Expression in Follicular and Papillary Thyroid Neoplasm.

Autor:	Miskad UA; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia., Aswidah A; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia., Dahlan H; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia., Ikram D; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia.; Department of Histology, Faculty of Medicine, Universitas Muslim Indonesia., Cangara MH; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia., Djimahit T; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia., Kaelan C; Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia.
Jazyk:	angličtina
Zdroj:	Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2022 Dec 01; Vol. 23 (12), pp. 4023-4027. Date of Electronic Publication: 2022 Dec 01.
DOI:	10.31557/APJCP.2022.23.12.4023
Abstrakt:	Objective: This study evaluated differences in Claudin-1 expression between follicular adenoma (FA), follicular thyroid carcinoma (FTC), follicular variant papillary thyroid carcinoma (FV-PTC), and papillary thyroid carcinoma (PTC). Material and Methods: This study used a cross-sectional approach. Immunostaining using the polyclonal antibody Claudin-1 was performed on 75 samples divided into 20 samples for follicular adenoma, follicular thyroid carcinoma, papillary carcinoma, and 15 samples of follicular variant thyroid carcinoma, respectively. Results: Claudin-1 expression is detected on the cytoplasmic membrane of tumor cells and appears to be varied among thyroid neoplasms. The claudin-1 expression score revealed a statistically significant difference between FA against FV-PTC, FA versus (vs) PTC, and FTC vs PTC, with median values of 4 vs 6 (p = 0.016), 4 vs 8 (p = 0.001), and 5 vs 8 (p = 0.002), respectively. However, there was no statistically significant difference in scores between the FA and the FTC (4 vs 5), or between the FTC and the FV-PTC groups (5 vs 6 (p=1,000). Conclusion: These results suggest that Claudin-1 may be capable of discriminating follicular adenoma from classic and follicular variant of papillary thyroid carcinoma. It can also differentiate follicular thyroid carcinoma and papillary thyroid carcinoma, especially for cases challenging to assess by hematoxylin and eosin staining. It still holds promise in providing targeted cancer therapy.
Databáze:	MEDLINE
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