Inflammation and cognition in severe mental illness: patterns of covariation and subgroups.

Autor: Sæther LS; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. l.s.sather@psykologi.uio.no.; Department of Psychology, University of Oslo, Oslo, Norway. l.s.sather@psykologi.uio.no., Ueland T; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Haatveit B; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Maglanoc LA; University Centre for Information Technology, University of Oslo, Oslo, Norway., Szabo A; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Djurovic S; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Genetics, Oslo University Hospital/University of Oslo, Oslo, Norway., Aukrust P; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Roelfs D; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Mohn C; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ormerod MBEG; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lagerberg TV; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Steen NE; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Melle I; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Andreassen OA; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ueland T; Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2023 Mar; Vol. 28 (3), pp. 1284-1292. Date of Electronic Publication: 2022 Dec 28.
DOI: 10.1038/s41380-022-01924-w
Abstrakt: A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual variance in both cognitive functioning and inflammatory/immune status. This study aimed to investigate covariance patterns between inflammatory/immune-related markers and cognitive domains and further elucidate heterogeneity in a large SMI and healthy control (HC) cohort (SZ = 343, BD = 289, HC = 770). We applied canonical correlation analysis (CCA) to identify modes of maximum covariation between a comprehensive selection of cognitive domains and inflammatory/immune markers. We found that poor verbal learning and psychomotor processing speed was associated with higher levels of interleukin-18 system cytokines and beta defensin 2, reflecting enhanced activation of innate immunity, a pattern augmented in SMI compared to HC. Applying hierarchical clustering on covariance patterns identified by the CCA revealed a high cognition-low immune dysregulation subgroup with predominantly HC (24% SZ, 45% BD, 74% HC) and a low cognition-high immune dysregulation subgroup predominantly consisting of SMI patients (76% SZ, 55% BD, 26% HC). These subgroups differed in IQ, years of education, age, CRP, BMI (all groups), level of functioning, symptoms and defined daily dose (DDD) of antipsychotics (SMI cohort). Our findings suggest a link between cognitive impairment and innate immune dysregulation in a subset of individuals with severe mental illness.
(© 2022. The Author(s).)
Databáze: MEDLINE
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