Oral oxycodone self-administration leads to features of opioid misuse in male and female mice.

Autor:	Slivicki RA; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Earnest T; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Chang YH; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Pareta R; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Casey E; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA., Li JN; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Tooley J; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Abiraman K; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Vachez YM; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Wolf DK; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Sackey JT; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA., Kumar Pitchai D; MCCI Corporation, Ithaca, New York, USA., Moore T; MCCI Corporation, Ithaca, New York, USA., Gereau RW 4th; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA., Copits BA; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri, USA., Kravitz AV; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA., Creed MC; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
Jazyk:	angličtina
Zdroj:	Addiction biology [Addict Biol] 2023 Jan; Vol. 28 (1), pp. e13253.
DOI:	10.1111/adb.13253
Abstrakt:	Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current opioid epidemic. There are several challenges with modelling oxycodone abuse. First, prescription opioids including oxycodone are orally self-administered and have different pharmacokinetics and dynamics than morphine or fentanyl, which have been more commonly used in rodent research. This oral route of administration determines the pharmacokinetic profile, which then influences the establishment of drug-reinforcement associations in animals. Moreover, the pattern of intake and the environment in which addictive drugs are self-administered are critical determinants of the levels of drug intake, of behavioural sensitization and of propensity to relapse behaviour. These are all important considerations when modelling prescription opioid use, which is characterized by continuous drug access in familiar environments. Thus, to model features of prescription opioid use and the transition to abuse, we designed an oral, homecage-based oxycodone self-administration paradigm. Mice voluntarily self-administer oxycodone in this paradigm without any taste modification such as sweeteners, and the majority exhibit preference for oxycodone, escalation of intake, physical signs of dependence and reinstatement of seeking after withdrawal. In addition, a subset of animals demonstrate drug taking that is resistant to aversive consequences. This model is therefore translationally relevant and useful for studying the neurobiological substrates of prescription opioid abuse. (© 2022 Society for the Study of Addiction.)
Databáze:	MEDLINE
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