Human biomonitoring guidance values (HBM-GVs) for priority substances under the HBM4EU initiative - New values derivation for deltamethrin and cyfluthrin and overall results.

Autor: Apel P; German Environment Agency (UBA), Corrensplatz 1, 14195, Berlin, Germany. Electronic address: petra.apel@uba.de., Lamkarkach F; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 Rue Pierre et Marie Curie, 94701, Maisons-Alfort, Cedex, France., Lange R; German Environment Agency (UBA), Corrensplatz 1, 14195, Berlin, Germany., Sissoko F; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 Rue Pierre et Marie Curie, 94701, Maisons-Alfort, Cedex, France., David M; German Environment Agency (UBA), Corrensplatz 1, 14195, Berlin, Germany., Rousselle C; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 Rue Pierre et Marie Curie, 94701, Maisons-Alfort, Cedex, France., Schoeters G; VITO Health, Flemish Institute for Technological Research, 2400, Mol, Belgium; Department of Biomedical Sciences, University of Antwerp, 2610, Antwerp, Belgium., Kolossa-Gehring M; German Environment Agency (UBA), Corrensplatz 1, 14195, Berlin, Germany.
Jazyk: angličtina
Zdroj: International journal of hygiene and environmental health [Int J Hyg Environ Health] 2023 Mar; Vol. 248, pp. 114097. Date of Electronic Publication: 2022 Dec 26.
DOI: 10.1016/j.ijheh.2022.114097
Abstrakt: The European Initiative HBM4EU aimed to further establish human biomonitoring across Europe as an important tool for determining population exposure to chemicals and as part of health-related risk assessments, thus making it applicable for policy advice. Not only should analytical methods and survey design be harmonized and quality assured, but also the evaluation of human biomonitoring data. For the health-related interpretation of the data within HBM4EU, a strategy for deriving health-based human biomonitoring guidance values (HBM-GVs) for both the general population and workers was agreed on. On this basis, HBM-GVs for exposure biomarkers of 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), phthalates (diethyl hexyl phthalate (DEHP), di-n-butyl phthalate (DnBP), diisobutyl phthalate (DiBP), butyl benzyl phthalate (BBzP), and bis-(2-propylheptyl) phthalate (DPHP)), bisphenols A and S, pyrethroids (deltamethrin and cyfluthrin), solvents (1-methyl-2-pyrrolidone (NMP), 1-ethylpyrrolidin-2-one (NEP), N-dimethylformamide (DMF), N,N-dimethylacetamide (DMAC)), the heavy metal cadmium and the mycotoxin deoxynivalenol (DON) were developed and assigned a level of confidence. The approach to HBM-GV derivations, results, and limitations in data interpretation with special focus on the pyrethroids are presented in this paper.
(Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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