A Breathable, Passive-Cooling, Non-Inflammatory, and Biodegradable Aerogel Electronic Skin for Wearable Physical-Electrophysiological-Chemical Analysis.

Autor: Zhu Y; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA., Haghniaz R; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA., Hartel MC; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Guan S; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.; Mork Family Department of Chemical Engineering & Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 90007, USA., Bahari J; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA., Li Z; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.; Mork Family Department of Chemical Engineering & Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 90007, USA., Baidya A; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Cao K; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA., Gao X; Department of Nanoengineering, University of California, San Diego, La Jolla, CA, 92093, USA., Li J; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA., Wu Z; Department of Nanoengineering, University of California, San Diego, La Jolla, CA, 92093, USA., Cheng X; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Li B; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.; Department of Manufacturing Systems Engineering and Management, California State University Northridge, Northridge, CA, 91330, USA., Emaminejad S; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Weiss PS; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Chemistry and Biochemistry, Department of Materials Science and Engineering and California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA., Khademhosseini A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2023 Mar; Vol. 35 (10), pp. e2209300. Date of Electronic Publication: 2023 Jan 20.
DOI: 10.1002/adma.202209300
Abstrakt: Real-time monitoring of human health can be significantly improved by designing novel electronic skin (E-skin) platforms that mimic the characteristics and sensitivity of human skin. A high-quality E-skin platform that can simultaneously monitor multiple physiological and metabolic biomarkers without introducing skin discomfort or irritation is an unmet medical need. Conventional E-skins are either monofunctional or made from elastomeric films that do not include key synergistic features of natural skin, such as multi-sensing, breathability, and thermal management capabilities in a single patch. Herein, a biocompatible and biodegradable E-skin patch based on flexible gelatin methacryloyl aerogel (FGA) for non-invasive and continuous monitoring of multiple biomarkers of interest is engineered and demonstrated. Taking advantage of cryogenic temperature treatment and slow polymerization, FGA is fabricated with a highly interconnected porous structure that displays good flexibility, passive-cooling capabilities, and ultra-lightweight properties that make it comfortable to wear for long periods of time. It also provides numerous permeable capillary channels for thermal-moisture transfer, ensuring its excellent breathability. Therefore, the engineered FGA-based E-skin can simultaneously monitor body temperature, hydration, and biopotentials via electrophysiological sensors and detect glucose, lactate, and alcohol levels via electrochemical sensors. This work offers a previously unexplored materials strategy for next-generation E-skin platforms with superior practicality.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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