Expression dynamics of lymphoid enhancer-binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis.

Autor: Song H; School of Medicine, Shanghai University, Shanghai, China.; School of Life Sciences, Shanghai University, Shanghai, China.; School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China., Zhao XB; School of Life Sciences, Shanghai University, Shanghai, China., Chu QS; School of Life Sciences, Shanghai University, Shanghai, China.; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China., Zhang J; School of Life Sciences, Shanghai University, Shanghai, China., Gao L; School of Life Sciences, Shanghai University, Shanghai, China., Liao XH; School of Life Sciences, Shanghai University, Shanghai, China.
Jazyk: angličtina
Zdroj: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2023 Apr; Vol. 252 (4), pp. 527-535. Date of Electronic Publication: 2023 Jan 05.
DOI: 10.1002/dvdy.562
Abstrakt: Background: Transcription factor lymphoid enhancer-binding factor 1 (LEF1) is a downstream mediator of the Wnt/β-catenin signaling pathway. It is expressed in dermal papilla and surrounding cells in the hair follicle, promoting cell proliferation, and differentiation.
Results: Here, we report that LEF1 is also expressed all through the hair cycle in the terminal Schwann cells (TSCs), a component of the lanceolate complex located at the isthmus. The timing of LEF1 appearance at the isthmus coincides with that of hair follicle innervation. LEF1 is not found at the isthmus in the aberrant hair follicles in nude mice. Instead, LEF1 in TSCs is found in the de novo hair follicles reconstituted on nude mice by stem cells chamber graft assay. Cutaneous denervation experiment demonstrates that the LEF1 expression in TSCs is independent of nerve endings. At last, LEF1 expression in the interfollicular epidermis during the early stage of skin development is significantly suppressed in transgenic mice with T-cell factor 3 (TCF3) overexpression.
Conclusion: We reveal the expression dynamics of LEF1 in skin during development and hair cycle. LEF1 expression in TSCs indicates that the LEF1/Wnt signal might help to establish a niche at the isthmus region for the lanceolate complex, the bulge stem cells and other neighboring cells.
(© 2022 American Association of Anatomists.)
Databáze: MEDLINE
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