Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial.
Autor: | Singh A; Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Iyer KV; Department of Anaesthesiology, Pain Medicine and Critical care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India., Maitra S; Department of Anaesthesiology, Pain Medicine and Critical care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India., Khanna P; Department of Anaesthesiology, Pain Medicine and Critical care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India., Sarkar S; Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, 751 019, India. drsoumyasarkar@yahoo.co.in., Ahuja V; Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India., Aravindan A; Department of Anaesthesiology, Pain Medicine and Critical care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India., Datta PK; Department of Anaesthesiology, Pain Medicine and Critical care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India., Ganesh V; Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India. |
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Jazyk: | angličtina |
Zdroj: | Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2022 Dec; Vol. 41 (6), pp. 583-590. Date of Electronic Publication: 2022 Dec 28. |
DOI: | 10.1007/s12664-022-01291-y |
Abstrakt: | Background: Optimum procedural sedation is very essential for conducting non-operating room procedures such as endoscopic retrograde cholangiopancreatography (ERCP). The combination of ketamine and dexmedetomidine (KD) is expected to balance out the undesirable effects of either drug and provide smooth sedation. Together ketamine and propofol (KP) also provide synergistic sedation with stable hemodynamics. This prospective, single-blinded randomized study aimed to compare the effect of both the combinations during ERCP in terms of oxygen desaturation, respiratory depression, hemodynamic parameters, analgesia, recovery time, and ease with which the endoscopist could perform the endoscopy. Methods: This prospective, single-blinded randomized study (CTRI/2019/08/020625) was conducted on 84, ASA (American Society of Anesthesiologists) physical status I or II patients, of age 18-65 years presenting for ERCP in a tertiary care center. They were randomized to receive either KD (n=42) or KP (n=42) combination during ERCP. Mean SPO Results: The mean SpO Conclusions: The combination of ketamine-dexmedetomidine for procedural sedation during ERCP is a safe alternative to ketamine-propofol with a better respiratory profile. Clinical Trial Number and Registry Url: CTRI/2019/08/020625 ( www.ctri.nic.in ). (© 2022. Indian Society of Gastroenterology.) |
Databáze: | MEDLINE |
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