Electrochemical reactions of highly active nitroxyl radicals with thiol compounds.

Autor: Kumano M; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan., Sugiyama K; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan., Sato F; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan., Komatsu S; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan., Watanabe K; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan., Ono T; School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-Machi, Koriyama, Fukushima, 963-8611, Japan., Yoshida K; School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-Machi, Koriyama, Fukushima, 963-8611, Japan., Sasano Y; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan., Iwabuchi Y; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan., Fujimura T; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan., Kashiwagi Y; School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-Machi, Koriyama, Fukushima, 963-8611, Japan. y-kashiwagi@pha.ohu-u.ac.jp., Sato K; Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi, 981-8558, Japan. satok@tohoku-mpu.ac.jp.
Jazyk: angličtina
Zdroj: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry [Anal Sci] 2023 Mar; Vol. 39 (3), pp. 369-374. Date of Electronic Publication: 2022 Dec 28.
DOI: 10.1007/s44211-022-00246-9
Abstrakt: Nitroxyl radicals are known to electrochemically oxidize thiols as well as alcohols and amines. In this study, a preliminary investigation of the electrochemical reaction of thiols with 9-azabicyclo[3.3.1]nonane N-oxyl (ABNO), 2-azaadamantane N-oxyl (AZADO), and nortropine N-oxyl (NNO), which are highly active due to their bicyclo structures, for use in electrochemical analysis was performed and the results were compared with those for a typical nitroxyl radical compound, 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO). Mercaptopropane sulfonic acid (MPS) was used as a model compound to investigate the electrochemical response in aqueous solution. In addition, electrochemical detection of glutathione, a biological thiol molecule, was performed.
(© 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.)
Databáze: MEDLINE
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