The impact of prostate biopsy on erectile and ejaculatory function: A prospective study.

Autor: Morelli M; Urology Unit, ASST Ospedale Manzoni, Lecco; University of Milan. michelemorelli4@gmail.com., Sampogna G; University of Milan; Urology Unit, Niguarda Hospital, Milan. gianluca.sampogna@unimi.it., Molteni S; Urology Unit, ASST Ospedale Manzoni, Lecco; University of Milan. samuele.molteni@unimi.it., Sciorio C; Urology Unit, ASST Ospedale Manzoni, Lecco. carminesciorio@gmail.com., Lorusso V; University of Milan. vito.vlorusso@gmail.com., Romano L; Unit of Urology, Department of Neurosciences, Reproductive Sciences, and Odontostomatology University of Naples 'Federico II', Naples. loryromano@hotmail.it., La Rocca R; Unit of Urology, Department of Neurosciences, Reproductive Sciences, and Odontostomatology University of Naples 'Federico II', Naples. robertolarocca87@gmail.com., Capece M; Unit of Urology, Department of Neurosciences, Reproductive Sciences, and Odontostomatology University of Naples 'Federico II', Naples. drmarcocapece@gmail.com., Zimarra A; Unit of Urology, Department of Neurosciences, Reproductive Sciences, and Odontostomatology University of Naples 'Federico II', Naples. assuzimarra@gmail.com., Napolitano L; Unit of Urology, Department of Neurosciences, Reproductive Sciences, and Odontostomatology University of Naples 'Federico II', Naples. dr.luiginapolitano@gmail.com., Verze P; Department of Medicine and Surgery 'Scuola Medica Salernitana', University of Salerno, Fisciano, Campania. pverze@unisa.it., Spirito L; Unit of Urology, Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli,', Naples. lorenzo.spirito@unicampania.it.
Jazyk: angličtina
Zdroj: Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica [Arch Ital Urol Androl] 2022 Dec 27; Vol. 94 (4), pp. 420-423. Date of Electronic Publication: 2022 Dec 27.
DOI: 10.4081/aiua.2022.4.420
Abstrakt: Objective: To evaluate the impact on erectile and ejaculatory function following transrectal ultrasound-guided biopsies of the prostate (TRUS-Bx) in sexually active men.
Methods: Monocentric prospective study from May 2021 to January 2022 of consecutive patients with suspected prostate cancer [elevated prostate specific antigen (PSA) level and/or abnormal digital rectal examination] undergoing TRUS-Bx. The 15-item version of the International Index of Erectile Function (IIEF-15), Premature Ejaculation Diagnostic Tool (PDET) and short form of Male Sexual Health Questionnaire (MSHQ-EjD Short Form) were assessed before, one and three months after TRUS-Bx. The primary endpoint was to evaluate the risk of temporary post-biopsy erectile and/or ejaculatory dysfunctions. The statistical significance was set as p value < 0.05.
Results: A total of 276 consecutive patients were included in the study. The median age, PSA and biopsy cores were 65 years (IQR 59-69), 7 ng/ml (IQR 5-9.7) and 16 (IQR 12-16), respectively. We compared the IIEF subdomains before TRUS-Bx vs. one or three months: the erectile function (EF) decreased after one month (p<0.001) but recovered after three months (p=0.833); the Orgasmic Function (OF), the Sexual Desire (SD), the Intercourse Satisfaction (IS), the Overall Satisfaction (OS), and Total IIEF decreased significantly after both one and three months compared to pre-biopsy values (p < 0.05). As for ejaculatory function (EjF), PDET, MSHQ-EjD Short Form 1, 2, 3 and MSHQ-EjD Short Form 4 scores decreased significantly after one month (p < 0.001), but they returned to pre-biopsy values after 3 months: p = 0.538, p = 0.071 and p = 0.098, respectively.
Conclusions: Our study proved that EF, assessed through IIEF- 15, and ejaculatory function, assessed through PDET and MSHQ-EjD Short Form, were negatively affected by TRUS-Bx one month after the procedure and recovered after three months. Interestingly, the other IIEF-15 subdomains (OF, SD, IS, OS and Total) resulted as significantly reduced also after 3 months: this issue highlights the importance of carefully considering the indication to TRUS-Bx.
Databáze: MEDLINE
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