Melatonin immunoreactivity of epidermal skin is higher in the evening than morning but does not account for erythema sensitivity.

Autor:	Nikkola V; Faculty of Medicine and Health Technology, Department of Dermatology and Venereology, Tampere University, Tampere, Finland.; Department of Dermatology and Allergology, Tampere University Hospital, Tampere, Finland.; Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland., Huotari-Orava R; Faculty of Medicine and Health Technology, Department of Pathology and FIMLAB, Tampere University, Tampere, Finland., Joronen H; Faculty of Medicine and Health Technology, Department of Dermatology and Venereology, Tampere University, Tampere, Finland.; Department of Dermatology and Allergology, Tampere University Hospital, Tampere, Finland.; Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland., Grönroos M; Faculty of Medicine and Health Technology, Department of Dermatology and Venereology, Tampere University, Tampere, Finland.; Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland., Kautiainen H; Unit of Primary Health Care, Department of General Practice, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Unit of Primary Health Care, Kuopio University, Kuopio, Finland., Ylianttila L; Non-Ionizing Radiation Surveillance, Radiation and Nuclear Safety Authority (STUK), Helsinki, Finland., Snellman E; Faculty of Medicine and Health Technology, Department of Dermatology and Venereology, Tampere University, Tampere, Finland.; Department of Dermatology and Allergology, Tampere University Hospital, Tampere, Finland.; Department of Dermatology, University of Turku, Turku, Finland., Partonen T; Department of Public Health, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Jazyk:	angličtina
Zdroj:	Chronobiology international [Chronobiol Int] 2023 Feb; Vol. 40 (2), pp. 132-144. Date of Electronic Publication: 2022 Dec 28.
DOI:	10.1080/07420528.2022.2157733
Abstrakt:	The skin is a site of melatonin synthesis, and melatonin has a role in protecting against ultraviolet radiation-induced damage. Ultraviolet B (UVB) induced erythema seems to vary between morning and evening. We investigated whether epidermal melatonin immunoreactivities in the morning differed from those in the evening, and whether UVB-induced erythema was associated with these melatonin immunoreactivities in healthy volunteers. Erythema sensitivity of the skin was determined in the morning and in the evening by scoring the Minimal Erythema Dose and quantifying the erythema index (EI). We took biopsies from the non-UVB-exposed skin of healthy volunteers (n = 39) in the morning and in the evening to study melatonin immunoreactivity with immunohistochemistry (IHC). In the IHC staining, there was more melatonin immunoreactivity in the evening than in the morning ( p < .001). Erythema was more pronounced in the evening than in the morning irradiated skin ( p < .001). The graded amount of melatonin immunoreactivity in the samples was not associated with the EI. We discovered melatonin immunoreactivity of the non-irradiated skin to vary diurnally. However, endogenous skin melatonin does not seem to be the reason why NB-UVB induces more erythema in the evening than in the morning.
Databáze:	MEDLINE
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