Curcumin loaded gold nanoparticles-chitosan/sodium alginate nanocomposite for nanotheranostic applications.

Autor: Kolathupalayam Shanmugam B; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Rajendran N; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Arumugam K; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Rangaraj S; Department of Biotechnology, Sona College of Arts and Science, Salem, Tamil Nadu, India., Subramani K; Laboratory of Cyanobacterial Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand., Srinivasan S; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Nayagam L; Department of Physics, Sethu Institute of Technology, Viruthunagar, Tamil Nadu, India., Aicher WK; Department of Urology, University of Tübingen Hospital, Tübingen, Germany., Venkatachalam R; Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.; Department of Physics, Dr. N. G. P. Arts and Science College, Coimbatore, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2023 May; Vol. 34 (7), pp. 875-892. Date of Electronic Publication: 2022 Dec 28.
DOI: 10.1080/09205063.2022.2151819
Abstrakt: A solvent casting technique was used for the preparation of biomimetic nanocomposites scaffolds at three various concentrations of Curcumin loaded gold nanoparticles (Cur-AuNPs-1, 1.5, and 2 ml) as filler materials with chitosan-sodium alginate composite. The physico-chemical properties of prepared Cu-Au NPs and biomimetic nanocomposites were analyzed using various characterization techniques. In vitro biocompatibility of biomimetic nanocomposites are determined using simulated body fluid for biomineralization property, HAp formation and phosphate buffer saline (PBS) for swelling property, protein adsorption. Antibacterial activity of Cur-Au NPs and their nanocomposites carried out against Escherichia coli ( E. coli ) and Staphylococcus aureus. In vitro cytotoxicity of Cur-AuNPs is identified against UC-6 and MDA-MB 231 cell lines. The use of above studies and activity of Cur-AuNPs with contain biomimetic nanocomposites can adoptable for nanotheranostics.
Databáze: MEDLINE
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