Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.

Autor:	Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhu X; Department of Statistics, The Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA., Clarke SL; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Vedantam S; Boston Children's Hospital, EndocrinologyBoston, MA, 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO, 63108, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Zajac GJM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA., Hilliard AT; VA Palo Alto Health Care Systems, Palo Alto, CA, USA., Wang Z; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Thorleifsson G; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland., Helgadottir A; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland., Gudbjartsson DF; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland., Holm H; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik, 101, Iceland., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sakaue S; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kanai M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Veturi Y; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Pacheco JA; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Lingren T; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kullo IJ; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., Takayama J; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., Martin HC; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK., Hunt KA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trivedi B; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Haessler J; Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Miller JE; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Usher Institute, The University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, EH16 4UX, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Rasheed A; Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Sengupta D; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Brown MR; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Yu K; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Gao Z; Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Mitchell RE; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bjerregaard AA; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, Postbox 90048~700, Sanhsia Dist, New Taipei City, 237101, Taiwan., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; Aragon Institute of Engineering Research, University of Zaragoza and Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales Y Nanomedicina, Spain., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Mauro P; Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy., Matteo F; Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy.; Dipartimento Di Scienze Biomediche, Università Degli Studi Di Sassari, Sardinia, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Dept of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Yang B; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Poveda A; Lund University Diabetes Center, Lund University, Malmö, Sweden., Kurbasic A; Lund University Diabetes Center, Lund University, Malmö, Sweden., Lamina C; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Forer L; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Bradfield JP; Quantinuum Research LLC, Wayne, PA, 19087, USA., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Daw E; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA., Vazquez-Moreno M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Benjamins JW; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK., Tsao NL; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Lo KS; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Zilhao NR; Icelandic Heart Association, 201, Kopavogur, Iceland., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim GmbH, 68163, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Yang J; School of Life Sciences, Westlake University, Hangzhou, 310024, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, Surrey, UK., Leonard HL; Laboratory of Neurogenetics, National Institute On Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Frank M; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain.; Hematology Department, Hospital Universitario Virgen de Las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK., Hutri-Kähönen N; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Huerta-Chagoya A; CONACYT, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico City, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Lyssenko V; Lund University Diabetes Center, Lund University, Malmö, Sweden.; Center for Diabetes Research, University of Bergen, Bergen, Norway., Nongmaithem SS; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Bayyana S; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Stringham HM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Irvin MR; Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea.; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, 06355, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Duke-NUS Medical School, Health Services and Systems Research, Singapore, 169857, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, 80045, USA., Prasad G; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India.; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Theusch E; Department of Pediatrics, University of California San Francisco, Oakland, CA, 94609, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, 01003, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, Dong Cheng District, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Chen S; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Liu F; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Banas B; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany., Nardone GG; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.; Department of Clinical Epidemiology, Institute of Health Informatics, University College London, London, UK., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Massachusetts General Hospital Cancer Center, Charlestown, MA, 02129, USA., Concas MP; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA.; Department of Engineering Technology, University of Houston-Sugarland, Houston, TX, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Bentley AR; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Doumatey AP; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Adeyemo AA; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Lee JY; Oneomics. Co. Ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-Ro, Bucheon-Si Gyeonggi-Do, 14585, Korea., Petersen ERB; Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark., Nielsen AA; Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Rayner NW; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Québec, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, 33521, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD, 4102, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Hidalgo B; Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands., van Setten J; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Liang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Tang H; Department of Genetics, Stanford University School of Medicine Stanford, Palo Alto, CA, 94305, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Jackson RD; Division of Endocrinology, Ohio State University, Columbus, OH, 43210, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA., Martin LW; School of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, 04103, Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Center for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, 6938501, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia., Kovacs P; University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany., Giardoglou T; Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, 17676, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 5650871, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 5650871, Japan., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kim EK; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital, SeoulIlsan, 03722, Korea., Adams HHH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Dept of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Asselbergs FW; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kraaijeveld AO; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, 3584CG, Utrecht, the Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW, 2145, Australia., Hewitt AW; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Liverpool St, Hobart, TAS, 7000, Australia.; Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, 3002, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Québec, Canada.; Centre Nutrition, Santé Et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Québec, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Tönjes A; University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia., Mori TA; Discipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Lee H; Department of Internal Medicine, EwhaWomans University School of Medicine, Seoul, Korea., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15232, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, 117609, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA., Polasek O; University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia.; Algebra University College, Ilica 242, Zagreb, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Physical Activity and Health, Paavo Nurmi Centre, Sports and Exercise Medicine Unit, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Bandinelli S; Local Health Unit Toscana Centro, Florence, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kato N; National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada Di Fiume 447, 34149, Trieste, Italy., Böger CA; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, , Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Jung B; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, , Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurology, Center for Translational and Systems Neuroimmunology, Columbia University Medical Center, New York, NY, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Mamakou V; Medical School, National and Kapodistrian University Athens, 75 M. Assias Street, 115 27, Athens, Greece.; Dromokaiteio Psychiatric Hospital, 124 61, Athens, Greece., Brown M; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Kutzerufer 1, 68167, Mannheim, Germany.; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland.; Privatpraxis Prof Jonas Und Dr Panda-Jonas, Heidelberg, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA., Tusié-Luna T; Unidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, 6000, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, 6000, Cebu City, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka., Krauss RM; Children's Hospital Oakland Research Institute, Oakland, CA, 94609, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Penninx B; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 07804, Korea., Attia J; Hunter Medical Research Institute, Newcastle, Australia.; Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, Australia.; Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, USA., Arnett DK; Office of the Provost, University of South Carolina, Columbia, SC, USA., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, 84132, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, P.O.Box 340, 00029, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, 00290, Helsinki, Finland., Chandak GR; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.; JSS Academy of Higher Education and Research, Mysuru, India., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, 02115, USA., Costanzo MC; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jang D; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burtt NP; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Villalpando CG; InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes, Cuernavaca, Mexico., Orozco L; Laboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Tai E; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, 119228, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK., Yokota M; Kurume University School of Medicine, Kurume, 830-0011, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, 07033, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, DD1 9SY, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Simonsick E; 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Jazyk:	angličtina
Zdroj:	Genome biology [Genome Biol] 2022 Dec 27; Vol. 23 (1), pp. 268. Date of Electronic Publication: 2022 Dec 27.
DOI:	10.1186/s13059-022-02837-1
Abstrakt:	Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk. (© 2022. The Author(s).)
Databáze:	MEDLINE
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