Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice.

Autor:	Bertram T; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Reimers D; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Lory NC; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Schmidt C; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Schmid J; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., C Heinig L; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Bradtke P; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Rattay G; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Zielinski S; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Hellmig M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Bartsch P; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Rohde H; Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Nuñez S; Facultad de Medicina y Ciencia, Universidad San Sebastián 7510602, Sede Los Leones, Chile.; Centro Ciencia & Vida 7780272, Santiago, Chile., Rosemblatt MV; Facultad de Medicina y Ciencia, Universidad San Sebastián 7510602, Sede Los Leones, Chile., Bono MR; Department of Biology, Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Nunoa 7800003, Chile., Gagliani N; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Immunology and Allergy Unit, Department of Medicine, Karolinska Institute and University Hospital, Solna, Stockholm 17176, Sweden., Sandrock I; Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany., Panzer U; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Prinz I; Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Institute of Systems Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Mittrücker HW; Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2210490120. Date of Electronic Publication: 2022 Dec 27.
DOI:	10.1073/pnas.2210490120
Abstrakt:	γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A + during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection.
Databáze:	MEDLINE
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