Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog.

Autor: Guarino AL; Blue Pearl Veterinary Partners, Rockville, Maryland, USA.; Small Animal Hospital, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA., Cagle LA; Diagnostic Laboratories, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA., Ehrhardt CM; Small Animal Hospital, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA., Beatty SSK; Diagnostic Laboratories, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.; Antech Diagnostics, Fountain Valley, California, USA., Stern JK; Diagnostic Laboratories, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.; Auburn University Clinical Pathology Laboratory, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA., Gilor C; Small Animal Hospital, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA., Specht AJ; Small Animal Hospital, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA., Londoño LA; Small Animal Hospital, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.; Capital Veterinary Specialists, Jacksonville, Florida, USA.
Jazyk: angličtina
Zdroj: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) [J Vet Emerg Crit Care (San Antonio)] 2023 Mar; Vol. 33 (2), pp. 247-256. Date of Electronic Publication: 2022 Dec 27.
DOI: 10.1111/vec.13275
Abstrakt: Objective: To describe the therapeutic protocol used to normalize severe hypertriglyceridemia in a dog.
Case Summary: A 7-month-old, 1.2-kg female Pomeranian presented with acute polyuria, polydipsia, and ocular discoloration. Diagnoses included diabetic ketosis, severe hypertriglyceridemia (>225 mmol/L [>20,000 mg/dl]), lipemia retinalis, and bilateral uveitis. The triglyceride concentration was near normal within 2 days of initiating treatment with fenofibrate, regular insulin constant rate infusion (CRI), manual therapeutic plasma exchange (TPE), and a low-fat diet. All clinical signs resolved. The dog has had no relapse of hypertriglyceridemia at the time of writing the manuscript, 6 months later, with continued treatment of diabetes mellitus.
New or Unique Information Provided: This is the first case report documenting the combination of fenofibrate, insulin CRI, and manual TPE for treatment of severe hyperlipidemia in a dog. Detailed protocols for manual TPE and a novel insulin CRI are provided. A discussion of multiple spurious biochemical and hematologic errors associated with the severe hypertriglyceridemia is also provided.
(© Veterinary Emergency and Critical Care Society 2022.)
Databáze: MEDLINE
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