Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents.
| Autor: | Shim JH; Department of Anatomy, Korea University College of Medicine, Seoul 02842, Korea., Gwak S; Department of Chemistry, Korea University, Seoul 02841, Korea., Ahn BK; Department of Anatomy, Korea University College of Medicine, Seoul 02842, Korea., Han H; Department of Chemistry, Korea University, Seoul 02841, Korea., Hong Y; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York 14642, United States., Shin OS; BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea. |
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| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2022 Dec 08; Vol. 7 (50), pp. 46146-46155. Date of Electronic Publication: 2022 Dec 08 (Print Publication: 2022). |
| DOI: | 10.1021/acsomega.2c04220 |
| Abstrakt: | d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. N -α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against both Gram-positive and -negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens. d-LAE coated on gold (AuNP) and silica (SiNP) nanoparticles has more efficient antibacterial activity than that of d-LAE alone. However, unlike d-LAE, d-PD has enhanced antibacterial activity upon being coated on AuNP. The antibacterial d-AASs and their nanocomposites with nanoparticles were synthesized in an environmentally friendly manner and are expected to be valuable new antimicrobial agents against multidrug-resistant (MDR) pathogens. Competing Interests: The authors declare no competing financial interest. (© 2022 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
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