Candida nivariensis , an emerging fungus causing peritonitis in a patient receiving peritoneal dialysis.

Autor:	Chamroensakchai T; Center of Excellence in Kidney Metabolic Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand., Sanaklang N; Fort Suranari Hospital, Nakhon Ratchasima, 30000, Thailand., Hurdeal VG; Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai, 57100, Thailand.; School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand., Banjongjit A; Nephrology Unit, Department of Medicine, Vichaiyut Hospital, Bangkok, 10400, Thailand., Hyde KD; Center of Excellence in Fungal Research, Mae Fah Luang University, Chiang Rai, 57100, Thailand., Kanjanabuch T; Center of Excellence in Kidney Metabolic Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.; Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.; CAPD Excellent Center, King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand.
Jazyk:	angličtina
Zdroj:	Medical mycology case reports [Med Mycol Case Rep] 2022 Dec 05; Vol. 39, pp. 5-7. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2023).
DOI:	10.1016/j.mmcr.2022.11.002
Abstrakt:	Fungal peritonitis (FP) is usually associated with poor patient outcomes and is mostly caused by non- albicans Candida species. We present a Candida nivariensis -associated peritonitis in a 68-year-old woman with end-stage kidney disease on peritoneal dialysis (PD). Biochemical profiling of the cultured yeast of the effluent sample did not adequately identify the yeast. Hence, molecular phylogeny and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) mass spectroscopy were employed which correctly identified the causative species, C. nivariensis . PD catheter was removed and oral fluconazole was promptly started according to the 2022 International Society for PD (ISPD) Peritonitis Guidelines. However, the patient achieved only a partial clinical response and eventually died. The susceptibility test showed that the pathogen was susceptible to amphotericin B and voriconazole but resistant to other triazoles. This report underlines the importance of identifying the species, though rarely reported, and the drug susceptibility of the organism. Competing Interests: TK has received consultancy fees from VISTERRA, ELEDON, Otsuka OLE, and Otsuka VISIONARY as country investigators and current recipient of the National Research Council of Thailand and received speaking honoraria from Astra Zeneca and Baxter Healthcare. The other authors declare that they have no relevant financial interests. (© 2022 The Authors.)
Databáze:	MEDLINE
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