Regulatory role of miRNAs in Wnt signaling pathway linked with cardiovascular diseases.

Autor:	Behera JK; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Bhattacharya M; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Mishra P; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Mishra A; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Dash AA; Department of Biosciences and Biotechnology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Kar NB; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Behera B; Department of Biosciences and Biotechnology, Fakir Mohan University, Vyasa Vihar, Balasore, 756089, Odisha, India., Patra BC; Department of Zoology, Vidyasagar University, Midnapore, 721102, West Bengal, India.
Jazyk:	angličtina
Zdroj:	Current research in pharmacology and drug discovery [Curr Res Pharmacol Drug Discov] 2022 Oct 01; Vol. 3, pp. 100133. Date of Electronic Publication: 2022 Oct 01 (Print Publication: 2022).
DOI:	10.1016/j.crphar.2022.100133
Abstrakt:	MicroRNAs (miRNAs) are discovered in science about 23 years ago. These are short, a series of non-coding, single-stranded and evolutionary conserved RNA molecules found in eukaryotic cells. It involved post-transcriptional fine-tune protein expression and repressing the target of mRNA in different biological processes. These miRNAs binds with the 3'-UTR region of specific mRNAs to phosphorylate the mRNA degradation and inhibit the translation process in various tissues. Therefore, aberrant expression in miRNAs induces numerous cardiovascular diseases and developmental defects. Subsequently, the miRNAs and Wnt singling pathway are regulating a cellular process in cardiac development and regeneration, maintain the homeostasis and associated heart diseases. In Wnt signaling pathway majority of the signaling components are expressed and regulated by miRNAs, whereas the inhibition or dysfunction of the Wnt signaling pathway induces cardiovascular diseases. Moreover, inadequate studies about the important role of miRNAs in heart development and diseases through Wnt signaling pathway has been exist still now. For this reason in present review we summarize and update the involvement of miRNAs and the role of Wnt signaling in cardiovascular diseases. We have discussed the mechanism of miRNA functions which regulates the Wnt components in cellular signaling pathway. The fundamental understanding of Wnt signaling regulation and mechanisms of miRNAs is quite essential for study of heart development and related diseases. This approach definitely enlighten the future research to provide a new strategy for formulation of novel therapeutic approaches against cardiovascular diseases. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
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