Novel Nanotechnological Strategies for Skin Anti-aging.

Autor:	Pozos-Nonato S; Departamento de Ingeniería y Tecnología (Sección Farmacia), Facultad de Estudios Superiores Cuautitlán- Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740, Mexico., Domínguez-Delgado CL; Departamento de Ingeniería y Tecnología (Sección Farmacia), Facultad de Estudios Superiores Cuautitlán- Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740, Mexico.; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA., Campos-Santander KA; Departamento de Ingeniería y Tecnología (Sección Farmacia), Facultad de Estudios Superiores Cuautitlán- Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740, Mexico., Benavides AA; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA., Pacheco-Ortin SM; Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740, Mexico., Higuera-Piedrahita RI; Unidad de Investigación Multidisciplinaria-L 3, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan, Cuautitlán Izcalli, 54714, Mexico., Resendiz-González G; Unidad de Investigación Multidisciplinaria-L 3, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan, Cuautitlán Izcalli, 54714, Mexico., Molina-Trinidad EM; Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, Hidalgo, 42160, Mexico.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical biotechnology [Curr Pharm Biotechnol] 2023; Vol. 24 (11), pp. 1397-1419.
DOI:	10.2174/1389201024666221223095315
Abstrakt:	Background: Nanoparticle formulations development for anti-aging treatment is increasing due to their multifunctional properties. These nanotechnological strategies can target cellular/ molecular pathways of the skin affected by the aging process. However, a review of these strategies is required to discuss their efficacy/safety and establish the needs for further research. Objective: Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized and discussed in this work. Methods: The information in this review was extracted from recent and relevant studies using nanotechnology for anti-aging treatment from scientific databases. Results and Discussion: Results show an enhanced skin anti-aging effect of actives-loaded nanoparticles of next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes, niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared with nanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as, flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin, silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic, rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and other compounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin, botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skin rejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability, and effectivity for skin anti-aging, providing a controlled drug release with minimized side effects. Conclusion: Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles, enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin. Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to the clinic/industry. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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