Keeping an eye on circadian time in clinical research and medicine.

Autor: Klerman EB; Department of Neurology, Massachusetts General Hospital, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA., Brager A; Plans, Analysis, and Futures, John F. Kennedy Special Warfare Center and School, Fort Bragg, North Carolina, USA., Carskadon MA; Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, EP Bradley Hospital, Chronobiology and Sleep Research, Providence, Rhode Island, USA., Depner CM; Department of Health and Kinesiology, University of Utah, Salt Lake City, Utah, USA., Foster R; Sir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Goel N; Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA., Harrington M; Neuroscience Program, Smith College, Northampton, Massachusetts, USA., Holloway PM; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Knauert MP; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA., LeBourgeois MK; Sleep and Development Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Lipton J; Boston Children's Hospital and Kirby Neurobiology Center, Boston, Massachusetts, USA., Merrow M; Institute of Medical Psychology, Faculty of Medicine, LMU, Munich, Germany., Montagnese S; Department of Medicine, University of Padova, Padova, Italy.; Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Ning M; Clinical Proteomics Research Center and Cardio-Neurology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ray D; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Scheer FAJL; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Shea SA; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA., Skene DJ; Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK., Spies C; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitaetsmedizin Berlin, Berlin, Germany., Staels B; Univ, Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France., St-Onge MP; Division of General Medicine and Center of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Tiedt S; Institute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany., Zee PC; Center for Circadian and Sleep Medicine, Division of Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Burgess HJ; Sleep and Circadian Research Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Jazyk: angličtina
Zdroj: Clinical and translational medicine [Clin Transl Med] 2022 Dec; Vol. 12 (12), pp. e1131.
DOI: 10.1002/ctm2.1131
Abstrakt: Background: Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviours such as sleep/wake, eating/fasting, rest/activity, posture changes and exercise. For many research and clinical purposes, it is important to understand the contribution of the endogenous circadian component to these observed rhythms.
Content: The goal of this manuscript is to provide guidance on best practices in measuring metrics of endogenous circadian rhythms in humans and promote the inclusion of circadian rhythms assessments in studies of health and disease. Circadian rhythms affect all aspects of physiology. By specifying minimal experimental conditions for studies, we aim to improve the quality, reliability and interpretability of research into circadian and daily (i.e., time-of-day) rhythms and facilitate the interpretation of clinical and translational findings within the context of human circadian rhythms. We describe protocols, variables and analyses commonly used for studying human daily rhythms, including how to assess the relative contributions of the endogenous circadian system and other daily patterns in behaviours or the environment. We conclude with recommendations for protocols, variables, analyses, definitions and examples of circadian terminology.
Conclusion: Although circadian rhythms and daily effects on health outcomes can be challenging to distinguish in practice, this distinction may be important in many clinical settings. Identifying and targeting the appropriate underlying (patho)physiology is a medical goal. This review provides methods for identifying circadian effects to aid in the interpretation of published work and the inclusion of circadian factors in clinical research and practice.
(© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)
Databáze: MEDLINE
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