Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models.

Autor: Barreto AD; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC 27708, USA., Burt MA; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Musah S; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Cell Biology, Duke University, Durham, NC 27710, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC 27708, USA; Developmental and Stem Cell Biology Program, Duke MEDx Investigator, Duke University, Durham, NC 27710, USA; Duke Regeneration Center, Duke University, Durham, NC 27710, USA. Electronic address: samira.musah@duke.edu.
Jazyk: angličtina
Zdroj: Trends in pharmacological sciences [Trends Pharmacol Sci] 2023 Apr; Vol. 44 (4), pp. 204-207. Date of Electronic Publication: 2022 Dec 22.
DOI: 10.1016/j.tips.2022.12.001
Abstrakt: Chronic kidney disease (CKD) is an epidemic that affects millions worldwide. The glomerulus, a specialized unit of the nephron, is highly susceptible to injury. Human induced pluripotent stem cells (iPSCs) have emerged as an attractive resource for modeling kidney disease and therapeutic discovery.
Competing Interests: Declaration of interests None declared by the authors.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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