Effect of cyclosporin A on the toxicity of ivermectin, eprinomectin and moxidectin in populations of Rhipicephalus microplus.

Autor: Ferreira LC; Programa de Pós-Graduação em Ciência e Saúde Animal, Universidade Federal de Campina Grande (UFCG). Avenida Universitária s/n. Patos, Paraíba, Brazil., Lima EF; Departamento de Medicina Veterinária, Instituto Federal da Paraíba (IFPB), Avenida Presidente Tancredo Neves s/n. Sousa, Paraíba, Brazil., Silva ALP; Departamento de Medicina Veterinária, Instituto Federal da Paraíba (IFPB), Avenida Presidente Tancredo Neves s/n. Sousa, Paraíba, Brazil., Feitosa TF; Departamento de Medicina Veterinária, Instituto Federal da Paraíba (IFPB), Avenida Presidente Tancredo Neves s/n. Sousa, Paraíba, Brazil., Klafke GM; Centro de Pesquisa em Saúde Animal (IPVDF), Secretaria da Agricultura, Pecuária e Desenvolvimento Rural. Estrada do Conde, 6000. Eldorado do Sul, Rio Grande do Sul, Brazil., Vilela VLR; Programa de Pós-Graduação em Ciência e Saúde Animal, Universidade Federal de Campina Grande (UFCG). Avenida Universitária s/n. Patos, Paraíba, Brazil; Departamento de Medicina Veterinária, Instituto Federal da Paraíba (IFPB), Avenida Presidente Tancredo Neves s/n. Sousa, Paraíba, Brazil. Electronic address: vinicius.vilela@ifpb.edu.br.
Jazyk: angličtina
Zdroj: Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2023 Mar; Vol. 14 (2), pp. 102113. Date of Electronic Publication: 2022 Dec 20.
DOI: 10.1016/j.ttbdis.2022.102113
Abstrakt: Rhipicephalus microplus is mainly controlled by acaricides. However, reports of resistance to acaricides including macrocyclic lactones (MLs) have become frequent worldwide. Involvement of ABC transporters (ABCts) in populations resistant to ivermectin has been demonstrated. Thus, the aim of this study was to evaluate the efficacy of ivermectin, eprinomectin and moxidectin with and without use of synergistic cyclosporin A (CsA) in resistant populations of R. microplus using larval immersion tests (LITs). Engorged females were collected from four farms in the semiarid region of northeastern Brazil that had histories of continuous use of ivermectin. Questionnaires were applied to collect information about management aimed at controlling ticks on these farms. Resistance to MLs was observed on all of the farms. There was statistically significant synergism (p < 0.05) between CsA and ivermectin in all populations; between CsA and eprinomectin in only one population; and between CsA and moxidectin in two populations. It was concluded that, despite the involvement of ABCts in the mechanisms of resistance to ivermectin, metabolic detoxification does not seem to be the mechanism predominantly involved in resistance to eprinomectin and moxidectin in the populations of R. microplus evaluated.
(Copyright © 2022. Published by Elsevier GmbH.)
Databáze: MEDLINE
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