Long-term cortical plasticity following sensory deprivation is reduced in male Rett model mice.
| Autor: | Farhoomand F; Department of Biology, University of Victoria, Victoria, B.C, Canada., Delaney KR; Department of Biology, University of Victoria, Victoria, B.C, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Somatosensory & motor research [Somatosens Mot Res] 2023 Dec; Vol. 40 (4), pp. 133-140. Date of Electronic Publication: 2022 Dec 24. |
| DOI: | 10.1080/08990220.2022.2158799 |
| Abstrakt: | Purpose/aim: Rett (RTT) syndrome, a neurodevelopmental disorder, results from loss-of-function mutations in methyl-CpG-binding protein 2. We studied activity-dependent plasticity induced by sensory deprivation via whisker trimming in early symptomatic male mutant mice to assess neural rewiring capability. Methods: One whisker was trimmed for 0-14 days and intrinsic optical imaging of the transient reduction of brain blood oxygenation resulting from neural activation by 1 second of wiggling of the whisker stump was compared to that of an untrimmed control whisker. Results: Cortical evoked responses to wiggling a non-trimmed whisker were constant for 14 days, reduced for a trimmed whisker by 49.0 ± 4.3% in wild type ( n = 14) but by only 22.7 ± 4.6% in mutant ( n = 18, p = 0.001). Conclusion: As the reduction in neural activation following sensory deprivation in whisker barrel cortex is known to be dependent upon evoked and basal neural activity, impairment of cortical re-wiring following whisker trimming provides a paradigm suitable to explore mechanisms underlying deficiencies in the establishment and maintenance of synapses in RTT, which can be potentially targeted by therapeutics. |
| Databáze: | MEDLINE |
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