Systematic Review and Meta-Analyses of Word Production Abilities in Dysfunction of the Basal Ganglia: Stroke, Small Vessel Disease, Parkinson's Disease, and Huntington's Disease.

Autor: Camerino I; Donders Centre for Cognition, Radboud University, Nijmegen, The Netherlands., Ferreira J; Donders Centre for Cognition, Radboud University, Nijmegen, The Netherlands. joao.ferreira@donders.ru.nl., Vonk JM; Department of Neurology, Memory and Aging Center, University of California San Francisco (UCSF), San Francisco, CA, USA.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Kessels RPC; Donders Centre for Cognition, Radboud University, Nijmegen, The Netherlands.; Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.; Donders Centre for Medical Neuroscience, Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands., de Leeuw FE; Department of Neurology, Donders Centre for Medical Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands., Roelofs A; Donders Centre for Cognition, Radboud University, Nijmegen, The Netherlands., Copland D; School of Health and Rehabilitation Sciences, The University of Queensland, Saint Lucia, QLD, Australia.; Queensland Aphasia Research Centre, The University of Queensland, Herston, QLD, Australia., Piai V; Donders Centre for Cognition, Radboud University, Nijmegen, The Netherlands.; Donders Centre for Medical Neuroscience, Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: Neuropsychology review [Neuropsychol Rev] 2024 Mar; Vol. 34 (1), pp. 1-26. Date of Electronic Publication: 2022 Dec 24.
DOI: 10.1007/s11065-022-09570-3
Abstrakt: Clinical populations with basal ganglia pathologies may present with language production impairments, which are often described in combination with comprehension measures or attributed to motor, memory, or processing-speed problems. In this systematic review and meta-analysis, we studied word production in four (vascular and non-vascular) pathologies of the basal ganglia: stroke affecting the basal ganglia, small vessel disease, Parkinson's disease, and Huntington's disease. We compared scores of these clinical populations with those of matched cognitively unimpaired adults on four well-established production tasks, namely picture naming, category fluency, letter fluency, and past-tense verb inflection. We conducted a systematic search in PubMed and PsycINFO with terms for basal ganglia structures, basal ganglia disorders and language production tasks. A total of 114 studies were included, containing results for one or more of the tasks of interest. For each pathology and task combination, effect sizes (Hedges' g) were extracted comparing patient versus control groups. For all four populations, performance was consistently worse than that of cognitively unimpaired adults across the four language production tasks (p-values < 0.010). Given that performance in picture naming and verb inflection across all pathologies was quantified in terms of accuracy, our results suggest that production impairments cannot be fully explained by motor or processing-speed deficits. Our review shows that while language production difficulties in these clinical populations are not negligible, more evidence is necessary to determine the exact mechanism that leads to these deficits and whether this mechanism is the same across different pathologies.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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