[Experience of using bacteriophages in the complex treatment of children with aphthous stomatitis].

Autor:	Rabinovich IM; Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of the Russian Federation, Moscow, Russia., Gileva OS; Perm State Medical University named after Academician E.A. Wagner Ministry of the Ministry of Health of the Russian Federation, Perm, Russia., Akmalova GM; Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia., Mannapova GR; «Interdent» Dental clinic, Neftekamsk, Russia., Epishova AA; Ural State Medical University of the Ministry of Health of the Russian Federation, Yekaterinburg, Russia., Gimranova IA; Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia.
Jazyk:	ruština
Zdroj:	Stomatologiia [Stomatologiia (Mosk)] 2022; Vol. 101 (6), pp. 22-27.
DOI:	10.17116/stomat202210106122
Abstrakt:	Aphthous stomatitis (AS) is one of the most common diseases of the oral mucosa in children. A significant role in the pathogenesis of AS is assigned to the infectious-allergic factor. The Aim: Of the work was to evaluate the clinical effectiveness of topical application of bacteriophages in the complex treatment of children with aphthous stomatitis. Materials and Methods: The main group included 30 children with AS aged 4 to 15 years. The control group consisted of 20 healthy children without AS and without concomitant somatic pathology at the age of 4 to 15 years. The effectiveness of the therapy was evaluated based on the results of repeated bacteriological examination of the oral microflora, conducted 1 month after phage treatment, as well as the dynamics of clinical manifestations: reduction in size or complete epithelization of defects. Results: The use of bacteriophage in the complex treatment of children with AS was accompanied by positive dynamics of clinical and laboratory parameters in all patients: a significant decrease in microbial contamination and the number of individual pathogenic microflora species against the background of normalization of local microbiocenosis in the oral cavity. Conclusion: The obtained clinical and laboratory data allowed improving the scheme of complex treatment of AS in children by the use of bacteriophages.
Databáze:	MEDLINE
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