Amyloid Deposits in a Functionally Unicuspid Stenotic Aortic Valve.

Autor:	Zenses AS; Research Centre of the University of Montreal Hospital (CRCHUM), Montreal, Quebec, Canada., Leduc C; Department of Pathology and Cell Biology, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada., Béchard S; Department of Cardiology, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada., Forcillo J; Department of Surgery, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada., El Haffaf Z; Department of Genetic Medicine, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada., Do QB; Department of Surgery, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada., Pibarot P; Research Center of the Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Tournoux F; Department of Cardiology, University of Montreal Hospital (CHUM), Montreal, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	CJC open [CJC Open] 2022 Sep 22; Vol. 4 (12), pp. 1069-1073. Date of Electronic Publication: 2022 Sep 22 (Print Publication: 2022).
DOI:	10.1016/j.cjco.2022.09.002
Abstrakt:	Amyloidosis concomitant to aortic stenosis usually occurs with myocardial infiltration by the transthyretin protein. To our knowledge, this is the first report of localized amyloidosis of indeterminate type in a severely calcified and functionally unicuspid aortic valve. Isolated dystrophic valvular amyloidosis is believed to be related to fibrocalcific valve disease. In light of the literature on this topic, the present case raises new hypotheses on pathophysiology and further supports the contributory role of unusual non-tricuspid valve morphology in the development of dystrophic amyloid, likely secondary to altered hemodynamic stress. (© 2022 The Authors.)
Databáze:	MEDLINE
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