Ampelopsin targets in cellular processes of cancer: Recent trends and advances.

Autor:	Tuli HS; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207, India., Sak K; NGO Praeventio, Tartu 50407, Estonia., Garg VK; Department of Medical Laboratory Technology, University Institute of Applied Health Sciences, Chandigarh University, Gharuan, Mohali 140413, Punjab, India., Kumar A; Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India., Adhikary S; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai 40056, Maharashtra, India., Kaur G; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai 40056, Maharashtra, India., Parashar NC; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207, India., Parashar G; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207, India., Mukherjee TK; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207, India., Sharma U; Department of Zoology, Central University of Punjab, Village-Ghudda, 151401 Punjab, India., Jain A; Department of Zoology, Central University of Punjab, Village-Ghudda, 151401 Punjab, India., Mohapatra RK; Department of Chemistry, Government College of Engineering, Keonjhar 758002, Odisha, India., Dhama K; Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh 243122, India., Kumar M; Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala 134007, Haryana, India., Singh T; School of life Science, Jawaharlal Nehru University, New Delhi, India.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2022 Jul 27; Vol. 9, pp. 1614-1623. Date of Electronic Publication: 2022 Jul 27 (Print Publication: 2022).
DOI:	10.1016/j.toxrep.2022.07.013
Abstrakt:	Cancer is being considered as a serious threat to human health globally due to limited availability and efficacy of therapeutics. In addition, existing chemotherapeutic drugs possess a diverse range of toxic side effects. Therefore, more research is welcomed to investigate the chemo-preventive action of plant-based metabolites. Ampelopsin (dihydromyricetin) is one among the biologically active plant-based chemicals with promising anti-cancer actions. It modulates the expression of various cellular molecules that are involved in cancer progressions. For instance, ampelopsin enhances the expression of apoptosis inducing proteins. It regulates the expression of angiogenic and metastatic proteins to inhibit tumor growth. Expression of inflammatory markers has also been found to be suppressed by ampelopsin in cancer cells. The present review article describes various anti-tumor cellular targets of ampelopsin at a single podium which will help the researchers to understand mechanistic insight of this phytochemical. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu