A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma.

Autor:	Tymofiyeva O; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States., Hu R; Department of Psychiatry and Behavioral Sciences, The Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA, United States.; Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States., Kidambi R; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States., Nguyen C; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States., Max JE; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.; Rady Children's Hospital, San Diego, CA, United States., Yang TT; Department of Psychiatry and Behavioral Sciences, The Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA, United States.; Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2022 Dec 06; Vol. 16, pp. 1022791. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2022).
DOI:	10.3389/fnhum.2022.1022791
Abstrakt:	Introduction: Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment ( N = 379) and unexposed controls ( N = 348). Methods: Anisotropic effect size-signed differential mapping (AES-SDM) was utilized to synthesize the studies. Results: We observed increased volume amongst adolescents with a history of childhood trauma in regions that are involved in motor functions and language production: left precentral gyrus, including part of the left inferior frontal gyrus, left fibers of the body of corpus callosum, and left postcentral gyrus. We observed decreased volume amongst adolescents with a history of childhood trauma in regions that are involved in language processing and/or sensory processing: bilateral cerebellum, bilateral middle temporal gyrus, left rostrum of corpus callosum, and bilateral supramarginal gyrus. Discussion: We suggest that these morphometric differences may be reflective of impaired motor development and increased sensory sensitivity and hypervigilance in adolescents with experiences of childhood trauma. Our results differ from meta-analytical findings in adults with history of childhood trauma and may contribute to a better understanding of neural mechanisms of childhood trauma, prediction of neurodevelopmental outcomes, and development of more effective and personalized therapies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Tymofiyeva, Hu, Kidambi, Nguyen, Max and Yang.)
Databáze:	MEDLINE
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