Divergent Trends in the Prevalence of Children's Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia.

Autor:	Topalušić I; Division of Pulmology, Immunology, Allergology and Rheumatology, Department of Paediatrics, University Children's Hospital Zagreb, 10 000 Zagreb, Croatia., Stipić Marković A; Department of Pulmology, Special Hospital for Pulmonary Diseases, 10 000 Zagreb, Croatia., Artuković M; Department of Pulmology, Special Hospital for Pulmonary Diseases, 10 000 Zagreb, Croatia., Dodig S; Faculty of Pharmacy and Biochemistry, University of Zagreb, 10 000 Zagreb, Croatia., Bucić L; Division for Environmental Health, Croatian Institute for Public Health, 10 000 Zagreb, Croatia., Lugović Mihić L; Department of Dematology, School of Dental Medicine, Clinical Hospital Center Sisters of Mercy, 10 000 Zagreb, Croatia.
Jazyk:	angličtina
Zdroj:	Children (Basel, Switzerland) [Children (Basel)] 2022 Nov 22; Vol. 9 (12). Date of Electronic Publication: 2022 Nov 22.
DOI:	10.3390/children9121788
Abstrakt:	Background: Previous studies have reported that the allergy epidemic in developed countries has reached its plateau, while a rise is expected in developing ones. Our aim was to compare the prevalence of allergic diseases among schoolchildren from the city of Zagreb, Croatia after sixteen years. Methods: Symptoms of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) and risk factors were assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. An allergic profile was determined by a skin prick test. Results: The prevalence of current, ever-in-a-lifetime and diagnosed AR of 35.7%, 42.5% and 14.9% and AD of 18.1%, 37.1% and 31.1% demonstrated a significant increase. The asthma prevalence has remained unchanged. The allergen sensitivity rate has remained similar, but pollens have become dominant. Mould and dog exposure are risks for asthma (OR 14.505, OR 2.033). Exposure to cat allergens is protective in AR (OR 0.277). Parental history of allergies is a risk factor in all conditions. Conclusion: Over sixteen years, the prevalence of AR and AD, but not of asthma, have increased. The proportion of atopy has remained high. The AR/AD symptom rise is probably a consequence of increased pollen sensitisation united with high particulate matter concentrations. The stable asthma trend could be a result of decreasing exposures to indoor allergens.
Databáze:	MEDLINE
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