Role of Senescent Cells in Cutaneous Wound Healing.

Autor:	Andrade AM; UConn Center on Aging, UConn Health, Farmington, CT 06030, USA., Sun M; UConn Center on Aging, UConn Health, Farmington, CT 06030, USA., Gasek NS; UConn Center on Aging, UConn Health, Farmington, CT 06030, USA., Hargis GR; UConn School of Medicine, UConn Health, Farmington, CT 06030, USA., Sharafieh R; Department of Surgery, UConn Health, Farmington, CT 06030, USA., Xu M; UConn Center on Aging, UConn Health, Farmington, CT 06030, USA.
Jazyk:	angličtina
Zdroj:	Biology [Biology (Basel)] 2022 Nov 29; Vol. 11 (12). Date of Electronic Publication: 2022 Nov 29.
DOI:	10.3390/biology11121731
Abstrakt:	Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes, tumorigenesis, development, and wound repair amongst other processes and pathologies. Recent findings reveal that senescent cells can both promote and inhibit cutaneous wound healing processes. Relating senescent cells in acute and chronic wounds will help to clarify their role in wound healing processes and inform our understanding of senescent cell heterogeneity. To clarify this apparent contradiction and guide future research and therapeutic development, we will review the rapidly growing field of cellular senescence and its role in wound healing biology.
Databáze:	MEDLINE
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