Shedding a Light on the Challenges of Adolescents and Young Adults with Rhabdomyosarcoma.

Autor: Ferrari A; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy., Gatz SA; Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK., Minard-Colin V; Department of Paediatric and Adolescent Oncology, Gustave-Roussy, Cancer Campus, Université Paris-Saclay, 94805 Villejuif, France., Alaggio R; Pathology Department, Ospedale Pediatrico Bambino Gesù IRCCS, 00165 Roma, Italy., Hovsepyan S; Pediatric Cancer and Blood Disorders Centre of Armenia, Yerevan 0014, Armenia., Orbach D; SIREDO Oncology Center, Institut Curie, PSL University, 75005 Paris, France., Gasparini P; Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy., Defachelles AS; Department of Paediatric and AYA Oncology, Oscar Lambret Cancer Center, 59000 Lille, France., Casanova M; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy., Milano GM; Hematology/Oncology, Ospedale Pediatrico Bambino Gesù IRCCS, 00165 Roma, Italy., Chisholm JC; Children and Young People's Unit, Royal Marsden Hospital and The Institute of Cancer Research, Sutton SM2 5PT, UK., Jenney M; Department of Paediatric Oncology, Children's Hospital for Wales, Heath Park, Cardiff CF14 4XW, UK., Bisogno G; Hematology Oncology Division, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy., Rogers T; Department of Paediatric Surgery, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS1 3NU, UK., Mandeville HC; Department of Radiotherapy, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton SM2 5PT, UK., Shipley J; Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK., Miah AB; Sarcoma Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London SM2 5NG, UK., Merks JHM; Princess Máxima Center for Paediatric Oncology, 3584 CS Utrecht, The Netherlands., van der Graaf WTA; Department of Medical Oncology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3062 PA Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Dec 09; Vol. 14 (24). Date of Electronic Publication: 2022 Dec 09.
DOI: 10.3390/cancers14246060
Abstrakt: Rhabdomyosarcoma (RMS) is a typical tumour of childhood but can occur at any age. Several studies have reported that adolescent and young adult (AYA) patients with RMS have poorer survival than do younger patients. This review discusses the specific challenges in AYA patients with pediatric-type RMS, exploring possible underlying factors which may influence different outcomes. Reasons for AYA survival gap are likely multifactorial, and might be related to differences in tumor biology and intrinsic aggressiveness, or differences in clinical management (that could include patient referral patterns, time to diagnosis, enrolment into clinical trials, the adequacy and intensity of treatment), as well as patient factors (including physiology and comorbidity that may influence treatment tolerability, drug pharmacokinetics and efficacy). However, improved survival has been reported in the most recent studies for AYA patients treated on pediatric RMS protocols. Different strategies may help to further improve outcome, such as supporting trans-age academic societies and national/international collaborations; developing specific clinical trials without upper age limit; defining integrated and comprehensive approach to AYA patients, including the genomic aspects; establishing multidisciplinary tumor boards with involvement of both pediatric and adult oncologists to discuss all pediatric-type RMS patients; developing dedicated projects with specific treatment recommendations and registry/database.
Databáze: MEDLINE
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