| Autor: |
Perigo CV; Instituto Agronômico, Campinas 13075-630, Brazil., Haber LL; Vegetables Research Center, Brazilian Agricultural Research Corporation, Brasília 70351-970, Brazil., Facanali R; Instituto Agronômico, Campinas 13075-630, Brazil., Vieira MAR; Instituto Agronômico, Campinas 13075-630, Brazil., Torres RB; Instituto Agronômico, Campinas 13075-630, Brazil., Bernacci LC; Instituto Agronômico, Campinas 13075-630, Brazil., Guimarães EF; Instituto de Pesquisas Jardim Botânico do Rio de Janeiro, Rio de Janeiro 22460-030, Brazil., Baitello JB; Instituto Florestal do Estado de São Paulo, São Paulo 02377-000, Brazil., Sobral MEG; Natural Sciences Department, Campus Dom Bosco, Universidade Federal de São João del-Rei, São João del Reio 36301-160, Brazil., Quecini V; Grape and Wine Research Center, Brazilian Agricultural Research Corporation, Bento Gonçalves 95701-008, Brazil., Marques MOM; Instituto Agronômico, Campinas 13075-630, Brazil. |
| Abstrakt: |
Microbial resistance, caused by the overuse or inadequate application of antibiotics, is a worldwide crisis, increasing the risk of treatment failure and healthcare costs. Plant essential oils (EOs) consist of hydrophobic metabolites with antimicrobial activity. The antimicrobial potential of the chemical diversity of plants from the Atlantic Rainforest remains scarcely characterized. In the current work, we determined the metabolite profile of the EOs from aromatic plants from nine locations and accessed their antimicrobial and biocidal activity by agar diffusion assays, minimum inhibitory concentration, time-kill and cell-component leakage assays. The pharmacokinetic properties of the EO compounds were investigated by in silico tools. More than a hundred metabolites were identified, mainly consisting of sesqui and monoterpenes. Individual plants and botanical families exhibited extensive chemical variations in their EO composition. Probabilistic models demonstrated that qualitative and quantitative differences contribute to chemical diversity, depending on the botanical family. The EOs exhibited antimicrobial biocidal activity against pathogenic bacteria, fungi and multiple predicted pharmacological targets. Our results demonstrate the antimicrobial potential of EOs from rainforest plants, indicate novel macromolecular targets, and contribute to highlighting the chemical diversity of native species. |
