Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates.

Autor: Kayitmazer AB; Department of Chemistry, Bogazici University, Istanbul 34342, Turkey., Comert F; Department of Chemistry, Bogazici University, Istanbul 34342, Turkey., Winter HH; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA.; Department of Polymer Science & Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA., Messersmith PB; Department of Bioengineering, University of California, Berkeley, CA 94720, USA.; Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA.; Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2022 Dec 05; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 05.
DOI: 10.3390/biom12121817
Abstrakt: Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI coacervates depends strongly on the molecular weight of the polymers. Moduli for coacervates were found significantly higher than those of individual HA and CHI physical gels. A remarkable 1.5-fold increase in moduli was noted when catechol-conjugated HA and CHI were used instead. This was attributed to the conversion of coacervates to chemical gels by oxidation of 3,4-dihydroxyphenylalanine (DOPA) groups in HA and CHI to di-DOPA crosslinks. These rheological results put HA/CHI coacervates in the category of strong candidates as injectable tissue scaffolds or medical adhesives.
Databáze: MEDLINE
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