Risk of ovarian cancer in women who give birth after assisted reproductive technology (ART)-a registry-based Nordic cohort study with follow-up from first pregnancy.

Autor: Sandvei MS; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. marie.s.sandvei@ntnu.no.; The Cancer Clinic, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. marie.s.sandvei@ntnu.no., Pinborg A; The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Gissler M; Department of Knowledge Brokers, THL Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Academic Primary Health Care Centre, Region Stockholm, Sweden., Bergh C; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden., Romundstad LB; Spiren Fertility Clinic, Trondheim, Norway.; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., van Leeuwen FE; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Spaan M; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Tiitinen A; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Wennerholm UB; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden., Henningsen AK; The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Opdahl S; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 2023 Mar; Vol. 128 (5), pp. 825-832. Date of Electronic Publication: 2022 Dec 22.
DOI: 10.1038/s41416-022-02097-7
Abstrakt: Background: There is concern that assisted reproductive technology (ART) may increase ovarian cancer risk, but previous studies are inconclusive. We compared ovarian cancer risk for women who gave birth after ART vs natural conception.
Methods: Through linkage of nationwide registry data, we followed 3,303,880 initially nulliparous women in Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015) and Sweden (1985-2015) from first pregnancy ≥22 weeks to ovarian cancer, emigration, death or end of follow-up (2014/2015). We estimated hazard ratios (HRs), adjusting for age, parity, maternal birth year and country, and for body mass index and smoking in subsamples.
Results: Mean age at first birth was 27.7 years. During a mean follow-up of 14.4 person-years, 2683 participants (0.08%) developed ovarian cancer; 135 after ART and 2548 after natural conception only (incidence rates 11.6 and 5.5 per 100,000 person-years, respectively). The risk was higher for women who ever gave birth after ART (HR 1.70, 95% confidence interval 1.42-2.03) compared to natural conception. Associations were stronger for conventional in vitro fertilisation than for intracytoplasmic sperm injection.
Conclusions: Among parous women, ART-conception was associated with a higher risk of ovarian cancer than natural conception. Further studies should decipher whether this is causal or confounded by infertility or other factors.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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