Graphene Oxide-based Endodontic Sealer: An in Vitro Study.

Autor:	Nizami MZI; Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.; Research Core for Interdisciplinary Sciences, Okayama University.; Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong., Gorduysus M; Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.; European University of Lefke, Faculty of Dentistry, Department of Endodontics., Shinoda-Ito Y; Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University., Yamamoto T; Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University., Nishina Y; Research Core for Interdisciplinary Sciences, Okayama University.; Graduate School of Natural Science and Technology, Okayama University., Takashiba S; Research Core for Interdisciplinary Sciences, Okayama University., Arias Z; Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Jazyk:	angličtina
Zdroj:	Acta medica Okayama [Acta Med Okayama] 2022 Dec; Vol. 76 (6), pp. 715-721.
DOI:	10.18926/AMO/64122
Abstrakt:	The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. Competing Interests: No potential conflict of interest relevant to this article was reported.
Databáze:	MEDLINE
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