Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis.

Autor:	Yang Z; Washington University in St Louis School of Medicine, St Louis, Missouri, USA., Zarate Rodriguez JG; Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri, USA., Beck H; Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri, USA., Byrnes K; Pathology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA., Trikalinos NA; Medical Oncology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA., Hammill CW; Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri, USA hammillc@wustl.edu.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2022 Dec 22; Vol. 15 (12). Date of Electronic Publication: 2022 Dec 22.
DOI:	10.1136/bcr-2022-251400
Abstrakt:	Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis of neuroendocrine tumour with PTEN and PRKAR1A alterations; 19 months, later, a recurrence of her pancreatic malignancy was discovered. The patient underwent repeat resection and this time immunohistochemical staining confirmed the diagnosis of acinar cell carcinoma. Staining for acinar cell carcinoma should be prompted based on clinical suspicion in context of PTEN or PRKAR1A mutation when appropriate. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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