Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis.

Autor: Amaral JK; Institute of Diagnostic Medicine of Cariri, Juazeiro do Norte, Ceará, Brazil. Electronic address: kennedyamaral@ufmg.br., Bingham CO 3rd; Johns Hopkins Arthritis Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Taylor PC; University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Windmill Road, Oxford, UK., Vilá LM; Division of Rheumatology, Allergy and Immunology, San Juan, Puerto Rico, USA., Weinblatt ME; John R. and Eileen K. Riedman Professor of Medicine, Harvard Medical School, USA., Schoen RT; Section of Rheumatology, Yale University School of Medicine, New Haven, CT, USA.
Jazyk: angličtina
Zdroj: Travel medicine and infectious disease [Travel Med Infect Dis] 2023 Mar-Apr; Vol. 52, pp. 102534. Date of Electronic Publication: 2022 Dec 20.
DOI: 10.1016/j.tmaid.2022.102534
Abstrakt: Chikungunya virus (CHIKV) infection results from transmission by the mosquito vector. Following an incubation period of 5-7 days, patients develop an acute febrile illness, chikungunya fever (CHIKF), characterized by high fevers, maculopapular rash, headaches, polyarthritis/arthralgias, myalgias, nausea, vomiting, and diarrhea. Joint pain is often severe, and most often involves the hands, the wrists, the ankles, and the metatarsal-phalangeal joints of the feet. Many patients recover within several weeks, but up to 50% develop chronic joint pain and swelling for more than 12 weeks, then we refer to these symptoms as chronic chikungunya arthritis (CCA). The pathogenesis of CCA is not well understood. In this article, we suggest that mesenchymal stem cells (MSCs) may play an important role in this pathogenesis. This heterogeneous group of multipotent cells, morphologically similar to fibroblasts, may undergo epigenetic changes capable of generating aberrant progenies. However, we believe that there is no need for a latent infection. In our pathogenic hypothesis, CHIKV infection of MSCs would cause epigenetic changes both in MSCs themselves and in their progenies, without the need for reactivation of dormant viruses.
Competing Interests: Declaration of competing interest All authors declare no relevant competing interests.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: