Magnetic Resonance Biomarkers and Neurological Outcome of Infants with Mild Hypoxic-Ischaemic Encephalopathy Who Progress to Moderate Hypoxic-Ischaemic Encephalopathy.

Autor:	Montaldo P; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; Department of Brain Sciences, Centre for Perinatal Neuroscience, Imperial College London, London, UK., Puzone S; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Caredda E; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Galdo F; Neonatal Intensive Care Unit, Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Pugliese U; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Maietta A; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Ascione S; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Diplomatico M; Neonatal Intensive Care Unit, AORN San Giuseppe Moscati, Avellino, Italy., Spagnuolo F; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Roma V; Department of Neonatology and NICU Pineta Grande Hospital, Castel Volturno, Italy., De Vivo M; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy., Carpentieri M; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Moschella S; Neonatal Intensive Care Unit, AORN San Giuseppe Moscati, Avellino, Italy., Giordano L; Department of Neonatology and NICU Pineta Grande Hospital, Castel Volturno, Italy., D'Amico A; Department of Radiology, 'Tortorella' Private Hospital, Salerno, Italy., Capristo C; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Travan L; Neonatal Intensive Care Unit, Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Chello G; Department of Neonatal Intensive Care, Monaldi Hospital, Naples, Italy., Miraglia Del Giudice E; Department of Neonatal Intensive Care, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Cirillo M; Department of Advanced Medical and Surgical Sciences, MRI Research Center SUN-FISM, University of Campania Luigi Vanvitelli, Naples, Italy.
Jazyk:	angličtina
Zdroj:	Neonatology [Neonatology] 2023; Vol. 120 (1), pp. 153-160. Date of Electronic Publication: 2022 Dec 22.
DOI:	10.1159/000527871
Abstrakt:	Background: There is increasing concern that infants with mild hypoxic-ischaemic encephalopathy (HIE) may develop seizures and progress to moderate HIE beyond the therapeutic window for cooling. Objective: The aim of this study was to examine the effect of therapeutic hypothermia on magnetic resonance imaging (MRI) biomarkers and neurological outcomes in infants with mild HIE and seizures within 24 h after birth. Methods: This study shows an observational cohort study on 366 (near)-term infants with mild HIE and normal amplitude-integrated electroencephalography background. Results: Forty-one infants showed progression (11.2%); 29/41 (70.7%) were cooled. Infants with progression showed cerebral metabolite perturbations and higher white matter injury scores compared to those without in both cooled and non-cooled groups (p = 0.001, p = 0.02). Abnormal outcomes were seen in 5/12 (42%) non-cooled and 7/29 (24%) cooled infants with progression (p = 0.26). Conclusions: Early biomarkers are needed to identify infants with mild HIE at risk of progression. Mild HIE infants with progression showed a higher incidence of brain injury and abnormal outcomes. (© 2022 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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