Biosystem design of Corynebacterium glutamicum for bioproduction.

Autor: Zha J; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi 710021, China., Zhao Z; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi 710021, China., Xiao Z; Department of Energy, Environmental and Chemical Engineering, Washington University in Saint Louis, MO 63130, USA., Eng T; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Mukhopadhyay A; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Koffas MA; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA., Tang YJ; Department of Energy, Environmental and Chemical Engineering, Washington University in Saint Louis, MO 63130, USA. Electronic address: yinjie.tang@seas.wustl.edu.
Jazyk: angličtina
Zdroj: Current opinion in biotechnology [Curr Opin Biotechnol] 2023 Feb; Vol. 79, pp. 102870. Date of Electronic Publication: 2022 Dec 20.
DOI: 10.1016/j.copbio.2022.102870
Abstrakt: Corynebacterium glutamicum, a natural glutamate-producing bacterium adopted for industrial production of amino acids, has been extensively explored recently for high-level biosynthesis of amino acid derivatives, bulk chemicals such as organic acids and short-chain alcohols, aromatics, and natural products, including polyphenols and terpenoids. Here, we review the recent advances with a focus on biosystem design principles, metabolic characterization and modeling, omics analysis, utilization of nonmodel feedstock, emerging CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) tools for Corynebacterium strain engineering, biosensors, and novel strains of C. glutamicum. Future research directions for developing C. glutamicum cell factories are also discussed.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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