| Autor: |
Vokina VA; FSBSI East-Siberian Institute of Medical and Ecological Research, 665826 Angarsk, Russia., Sosedova LM; FSBSI East-Siberian Institute of Medical and Ecological Research, 665826 Angarsk, Russia., Novikov MA; FSBSI East-Siberian Institute of Medical and Ecological Research, 665826 Angarsk, Russia., Titov EA; FSBSI East-Siberian Institute of Medical and Ecological Research, 665826 Angarsk, Russia., Andreeva ES; FSBSI East-Siberian Institute of Medical and Ecological Research, 665826 Angarsk, Russia., Rukavishnikov VS; FSBSI East-Siberian Institute of Medical and Ecological Research, 665826 Angarsk, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Toxics [Toxics] 2022 Dec 01; Vol. 10 (12). Date of Electronic Publication: 2022 Dec 01. |
| DOI: |
10.3390/toxics10120750 |
| Abstrakt: |
This study aimed to follow the neurotoxic effect of peat smoke on adult outbred rats and its influence on central nervous system (CNS) parameters in first-generation offspring. Under experimental conditions, exposure to peat smoke was carried out on adult male Wistar rats for 24 h. After the end of the exposure, an open field test (OFT), electroencephalography (EEG), and histological analysis of the testes and brains of smoke-exposed males were performed, after which they were mated with intact females to obtain F1 offspring. Stillbirth, neonatal mortality, and body weight at 4, 7, 14, and 21 postnatal days, as well as behavior in the OFT and EEG parameters during puberty (3 months), were assessed. The results of the examination of F0 males showed a significant increase in motor activity and anxiety in the open field test and a violation of EEG parameters. Histopathologically, peat smoke caused a sharp increase in shadow cells (homogeneous cells with pale-stained cytoplasm, in which the cell and nuclear membranes are not visualized) and degeneratively altered neurons in the brain; we found no changes in the testicles. Peat smoke exposure during preconception did not affect neonatal mortality and weight gain in F1 offspring. Adult females born to peat-smoke-exposed males showed an increase in locomotor activity, and the behavior of adult F1 males did not differ from the control. In F1 males, a statistically significant increase in slow-wave activity indices in the delta band was observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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