Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™).

Autor: Aiello EN; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy.; PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Greco LC; Neuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy.; NeMO Lab, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., La Tona A; Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy., Solca F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy., Torre S; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy., Carelli L; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy., Pain D; Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of Milan Institute, Milan, Italy., Radici A; Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of Milan Institute, Milan, Italy., Lizio A; Neuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy., Casiraghi J; Neuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy., Cerri F; Neuromuscular Omnicentre (NEMO), Fondazione Serena Onlus, Milan, Italy., Brugnera A; Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy., Compare A; Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy., Woolley S; Syneos Health, Morrisville, NC, USA., Murphy J; Biogen, Cambridge, MA, USA., Tremolizzo L; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Appollonio I; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Verde F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy.; Department of Pathophysiology and Transplantation, Dino Ferrari Center', Università degli Studi di Milano, Milan, Italy., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy.; Department of Pathophysiology and Transplantation, Dino Ferrari Center', Università degli Studi di Milano, Milan, Italy., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy.; Department of Pathophysiology and Transplantation, Dino Ferrari Center', Università degli Studi di Milano, Milan, Italy., Lunetta C; Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of Milan Institute, Milan, Italy., Sansone VA; PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.; Department of Biomedical Sciences of Health, University of Milan, Milan, Italy., Poletti B; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy. b.poletti@auxologico.it.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 Apr; Vol. 44 (4), pp. 1243-1249. Date of Electronic Publication: 2022 Dec 22.
DOI: 10.1007/s10072-022-06569-9
Abstrakt: Background: The present study aimed at (1) providing further validity and reliability evidence for the Italian version of the cognitive section of the ALS Cognitive Behavioral Screen (ALS-CBS™) and (2) testing its diagnostics within an Italian ALS cohort, as well as at (3) exploring its capability to discriminate patients from healthy controls (HCs).
Methods: N = 293 non-demented ALS patients were administered the cognitive sections of the ALS-CBS™ and Edinburgh Cognitive and Behavioural ALS Screen (ECAS). N = 96 HCs demographically matched with N = 96 patients were also administered the cognitive section of the ALS-CBS™. In patients, factorial and construct validity, internal reliability, and diagnostics against a defective score on the cognitive section of the ECAS were tested. Case-control discrimination was assessed via a logistic regression.
Results: ALS-CBS™ cognitive subscales were underpinned by a simple, unidimensional structure, internally reliable (McDonald's ω = 0.74), and mostly related with ECAS executive and fluency scores (r s  = 0.54-0.71). Both raw and age- and education-adjusted scores on the cognitive section of the ALS-CBS™ accurately detected ECAS-defined cognitive impairment (AUC = 0.80 and .88, respectively), yielding optimal error-based, information-based and unitary diagnostics. A cut-off of < 15.374 was identified on adjusted scores. The test was able to discriminate patients from HCs (p < 0.001).
Discussion: The cognitive section of the Italian ALS-CBS™ is a valid, reliable, and diagnostically sound ALS-specific screener for detecting frontotemporal, executive-/attentive-based cognitive inefficiency in non-demented ALS patients, being also able to discriminate them from normotypical individuals.
(© 2022. Fondazione Società Italiana di Neurologia.)
Databáze: MEDLINE
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