A convenient catalytic method for preparation of new tetrahydropyrido[2,3- d ]pyrimidines via a cooperative vinylogous anomeric based oxidation.

Autor: Sepehrmansourie H; Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University Hamedan 6517838683 Iran mahmoud8103@yahoo.com zolfi@basu.ac.ir mzolfigol@yahoo.com +988138380709 +988138282807., Kalhor S; Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University Hamedan 6517838683 Iran mahmoud8103@yahoo.com zolfi@basu.ac.ir mzolfigol@yahoo.com +988138380709 +988138282807., Zarei M; Department of Chemistry, Faculty of Science, University of Qom Qom 37185-359 Iran mahmoud8103@yahoo.com., Zolfigol MA; Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University Hamedan 6517838683 Iran mahmoud8103@yahoo.com zolfi@basu.ac.ir mzolfigol@yahoo.com +988138380709 +988138282807., Hosseinifard M; Department of Energy, Materials and Energy Research Center P.O. Box 31787-316 Karaj Iran m.hosseini@merc.ac.ir.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2022 Nov 30; Vol. 12 (53), pp. 34282-34292. Date of Electronic Publication: 2022 Nov 30 (Print Publication: 2022).
DOI: 10.1039/d2ra05655k
Abstrakt: In this study, a novel functionalized metal-organic frameworks MIL-125(Ti)-N(CH 2 PO 3 H 2 ) 2 was designed and synthesized via post-modification methodology. Then, MIL-125(Ti)-N(CH 2 PO 3 H 2 ) 2 as a mesoporous catalyst was applied for the synthesis of a wide range of novel tetrahydropyrido[2,3- d ]pyrimidines as bioactive candidate compounds by one-pot condensation reaction of 3-(1-methyl-1 H -pyrrol-2-yl)-3-oxopropanenitrile, 6-amino-1,3-dimethylpyrimidine-2,4(1 H ,3 H )-dione and aromatic aldehydes at 100 °C under solvent-free condition. Interestingly, the preparation of tetrahydropyrido[2,3- d ]pyrimidine was achieved via vinylogous anomeric based oxidation mechanism with a high yield and short reaction time.
Competing Interests: The authors declare no competing financial interests.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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