SLC2A9 rs1014290 Polymorphism is Associated with Prediabetes and Type 2 Diabetes.

Autor: Zhang X; Department of Rheumatism and Immunology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei 050000, China., Hou G; Department of Geriatric, Affiliated Hospital of Hebei Engineering University, 81 Congtai Road, Handan, Hebei 056000, China., Li F; Department of Rheumatism and Immunology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei 050000, China., Zheng X; Department of Rheumatism and Immunology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei 050000, China., Nie Q; Physical Examination Center, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei 050000, China., Song G; Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei 050000, China.
Jazyk: angličtina
Zdroj: International journal of endocrinology [Int J Endocrinol] 2022 Dec 12; Vol. 2022, pp. 4947684. Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2022).
DOI: 10.1155/2022/4947684
Abstrakt: Purpose: To investigate the association of the A/G rs1014290 polymorphism in SLC2A9 with type 2 diabetes (T2DM) and prediabetes mellitus (pre-DM). Patients and Methods . We enrolled 1058 patients who attended the Hebei General Hospital, Shijiazhuang, Hebei Province, China. The patients underwent general testing and oral glucose tolerance tests and were divided into three groups: 352 patients newly diagnosed with T2DM, 358 patients with pre-DM, and 348 healthy controls. The single nucleotide polymorphism (SNP) was detected by ligase detection reactions. The χ 2 test, one-way ANOVA, and binary logistic regression analysis were used to analyze the results.
Results: In the T2DM group, the GG genotype frequency at the rs1014290 locus was significantly lower (14.8%) than it was in the healthy controls. Furthermore, the GG genotype group was associated with a reduced risk of T2DM in unadjusted and confounder-adjusted models compared with the risk in the AA genotype group. The G allele in the SLC2A9 rs1014290 locus decreased susceptibility to T2DM. In the pre-DM group, the GG and AG genotype groups had no significant correlation with the risk of pre-DM in any of the models. In the T2DM group, the uric acid level was significantly lower in the GG genotype group. In the T2DM and pre-DM groups, the HOMA- β levels were significantly higher in the GA ( P   < 0.001) and GG ( P   < 0.001) genotype groups than it was in the AA genotype group, and HOMA-IR was significantly lower in the GA ( P   < 0.001) and GG ( P   < 0.001) genotype groups than it was in the AA genotype group.
Conclusion: The A/G (rs1014290) SNP in SLC2A9 is closely related to the occurrence and development of diabetes.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2022 Xuemei Zhang et al.)
Databáze: MEDLINE
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