ZIF-90 nanoparticles modified with a homing peptide for targeted delivery of cisplatin.

Autor:	Abubakar A; Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia (UPM), Seri Kembangan, Malaysia.; Department of Chemical Sciences, Taraba State University, P.M.B, Taraba State, Jalingo, Nigeria., Abdulmalek E; Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia (UPM), Seri Kembangan, Malaysia., Norhamidah Wan Ibrahim W; Department of Biology, Faculty of Science, UPM, Selangor Darul Ehsan, Malaysia., Cordova KE; Materials Discovery Research Unit, Advanced Research Centre, Royal Scientific Society, Amman, Jordan.; Department of Chemistry, Faculty of Science, UPM, Selangor Darul Ehsan, Malaysia.; Foundry of Reticular Materials for Sustainability (FORMS), Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, UPM, Selangor Darul Ehsan, Malaysia., Abdul Rahman MB; Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia (UPM), Seri Kembangan, Malaysia.; Department of Chemistry, Faculty of Science, UPM, Selangor Darul Ehsan, Malaysia.; Foundry of Reticular Materials for Sustainability (FORMS), Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, UPM, Selangor Darul Ehsan, Malaysia.
Jazyk:	angličtina
Zdroj:	Frontiers in chemistry [Front Chem] 2022 Dec 05; Vol. 10, pp. 1076350. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2022).
DOI:	10.3389/fchem.2022.1076350
Abstrakt:	To improve the selective delivery of cisplatin (Cis) to cancer cells, we report and establish the significance of active, targeting drug delivery nanosystems for efficient treatment of lung cancer. Specifically, pH-responsive nano-sized zeolitic imidazolate framework (nZIF-90) was synthesized, post-synthetically modified with an Arg-Gly-Asp peptide motif (RGD@nZIF-90), a known cancer cell homing peptide, and loaded with a large amount of Cis (RGD@Cis⊂nZIF-90). RGD@Cis⊂nZIF-90 was shown to be highly stable under physiological conditions (pH = 7.4) with framework dissociation occurring under slightly acidic conditions (pH = 5.0)-conditions relevant to tumor cells-from which 90% of the encapsulated Cis was released in a sustained manner. In vitro assays demonstrated that RGD@Cis⊂nZIF-90 achieved significantly better cytotoxicity (65% at 6.25 μg ml -1 ) and selectivity (selectivity index = 4.18 after 48 h of treatment) against adenocarcinoma alveolar epithelial cancer cells (A549) when compared with the unmodified Cis⊂nZIF-90 (22%). Cellular uptake using A549 cells indicated that RGD@Cis⊂nZIF-90 was rapidly internalized leading to significant cell death. After successfully realizing this nanocarrier system, we demonstrated its efficacy in transporting and delivering Cis to cancer cells. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with the author KC. (Copyright © 2022 Abubakar, Abdulmalek, Norhamidah Wan Ibrahim, Cordova and Abdul Rahman.)
Databáze:	MEDLINE
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