Recent advances in the dearomative functionalisation of heteroarenes.
| Autor: | Kratena N; Chemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK timothy.donohoe@chem.ox.ac.uk., Marinic B; Chemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK timothy.donohoe@chem.ox.ac.uk., Donohoe TJ; Chemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK timothy.donohoe@chem.ox.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical science [Chem Sci] 2022 Nov 17; Vol. 13 (48), pp. 14213-14225. Date of Electronic Publication: 2022 Nov 17 (Print Publication: 2022). |
| DOI: | 10.1039/d2sc04638e |
| Abstrakt: | Dearomatisation reactions of (hetero)arenes have been widely employed as efficient methods to obtain highly substituted saturated cyclic compounds for over a century. In recent years, research in this area has shifted towards effecting additional C-C bond formation during the overall dearomative process. Moving away from classical hydrogenation-based strategies a wide range of reagents were found to be capable of initiating dearomatisation through nucleophilic addition (typically a reduction) or photochemically induced radical addition. The dearomatisation process gives rise to reactive intermediates which can be intercepted in an intra- or intermolecular fashion to deliver products with significantly increased molecular complexity when compared to simple dearomatisation. In this Perspective recent examples and strategies for the dearomative functionalisation of heteroaromatic systems will be discussed. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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