Sinonasal lymphoma: A primer for otolaryngologists.

Autor: Bitner BF; Department of Otolaryngology - Head and Neck Surgery University of California Irvine Medical Center Orange California USA., Htun NN; Department of Pathology and Laboratory Medicine University of California Irvine Medical Center Orange California USA., Wang BY; Department of Pathology and Laboratory Medicine University of California Irvine Medical Center Orange California USA., Brem EA; Department of Medicine, Division of Hematology and Oncology University of California Irvine Medical Center Orange California USA., Kuan EC; Department of Otolaryngology - Head and Neck Surgery University of California Irvine Medical Center Orange California USA.; Department of Neurological Surgery University of California Irvine Medical Center Orange California USA.
Jazyk: angličtina
Zdroj: Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2022 Oct 04; Vol. 7 (6), pp. 1712-1724. Date of Electronic Publication: 2022 Oct 04 (Print Publication: 2022).
DOI: 10.1002/lio2.941
Abstrakt: Objective: Sinonasal lymphomas are a rare entity that commonly present with nonspecific sinonasal symptoms and are often recognized immediately. Through this review, we aim to summarize important principles in diagnosis and treatment of sinonasal lymphomas, with the goal of disseminating the current knowledge of this under-recognized malignancy to otolaryngologists.
Methods: Systemic review using PRISMA guidelines of foundational scholarly articles, guidelines, and trials were reviewed focusing on clinical characteristics of key sinonasal lymphoma subtypes, along with available treatments in the otolaryngology, medical oncology, and radiation oncology literature.
Results: Sinonasal lymphoma are derived from clonal proliferation of lymphocytes at various stages of differentiation, of which diffuse large B-cell lymphoma (DLBCL) and extranodal natural killer/T-cell lymphoma (ENKTL) are the most common. Diagnosis and staging require biopsy with immunohistochemistry in conjunction with imaging and laboratory studies. Treatment is ever evolving and currently includes multi-agent chemotherapy and/or radiation therapy.
Conclusion: Otolaryngologists may be the first to recognize sinonasal lymphoma, which requires a comprehensive workup and a multidisciplinary team for treatment. Symptoms are nonspecific and similar to many sinonasal pathologies, and it is crucial for otolaryngologists to keep a broad differential.
Level of Evidence: 5.
Competing Interests: The authors declare that they have no conflict of interest.
(© 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
Databáze: MEDLINE
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