Extracorporeal shock wave therapy in association with bromelain and escin for the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome.

Autor:	Palmieri A; Department of Neurosciences, Reproductive Sciences, Odontostomatology-Urology Unit, University of Naples 'Federico II', I-80100 Naples, Italy., Cai T; Department of Urology, Santa Chiara Regional Hospital, I-38123 Trento, Italy.; Institute of Clinical Medicine, University of Oslo, 0010 Oslo, Norway., Di Luise L; Department of Neurosciences, Reproductive Sciences, Odontostomatology-Urology Unit, University of Naples 'Federico II', I-80100 Naples, Italy., D'Alterio C; Department of Neurosciences, Reproductive Sciences, Odontostomatology-Urology Unit, University of Naples 'Federico II', I-80100 Naples, Italy., La Cava G; Department of Urology, A.s.p. Crotone, I-88900 Crotone, Italy., Cirigliano L; Department of Neurosciences, Reproductive Sciences, Odontostomatology-Urology Unit, University of Naples 'Federico II', I-80100 Naples, Italy., Di Giovanni A; Department of Neurosciences, Reproductive Sciences, Odontostomatology-Urology Unit, University of Naples 'Federico II', I-80100 Naples, Italy., Gallelli L; Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, I-88100 Catanzaro, Italy.; Department of Health Sciences, School of Medicine, University of Catanzaro, I-88100 Catanzaro, Italy.; Research Center FAS@UMG, Department of Health Sciences, University of Catanzaro, I-88100 Catanzaro, Italy., Capece M; Department of Neurosciences, Reproductive Sciences, Odontostomatology-Urology Unit, University of Naples 'Federico II', I-80100 Naples, Italy.
Jazyk:	angličtina
Zdroj:	Biomedical reports [Biomed Rep] 2022 Nov 25; Vol. 18 (1), pp. 7. Date of Electronic Publication: 2022 Nov 25 (Print Publication: 2023).
DOI:	10.3892/br.2022.1589
Abstrakt:	Extracorporeal shock wave therapy (ESWT) has been purposed for the management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with encouraging results. Phytotherapeutic compounds have been used in everyday clinical practice for patients with CP/CPSS due to their anti-inflammatory properties. The present study aimed to investigate the effects of ESWT in association with the use of bromelain and escin extracts in patients with CP/CPSS. For this purpose, 95 patients with a clinical diagnosis of CP/CPSS were enrolled in the study. The patients were randomly allocated to either the ESWT plus bromelain and escin group (group A; n=48) or the ESWT only group (group B; n=47). A total of five weekly ESWT treatment sessions were administered alone or in combination with bromelain and escin. Each session consisted of 3,000 focused shock waves. Doses of 160 and 500 mg/day bromelain and escin were administered respectively for 5 weeks. The changes in urinary symptoms, pain and quality of life were considered the main outcome measures and were assessed at baseline, and at 4, 12 and 24 weeks of follow-up. Urinary symptoms, pain and quality of life were evaluated using the international prostatic symptoms score (IPSS), visual analog scale (VAS) and the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI). After 4 weeks, the mean VAS score, mean IPSS and mean satisfaction rate score had significantly improved in patients receiving ESWT plus bromelain and escin. After 12 weeks, the mean IPSS and mean satisfaction rate score were stable in the ESWT plus bromelain and escin group, while the mean VAS score was significantly lower when compared with the baseline values in both groups. On the whole, the present study demonstrates that in patients affected by CP/CPPS, treatment with ESWT plus bromelain and escin leads to pain resolution, and both treatments improve the IPSS, VAS and NIH-CPSI results. Competing Interests: The authors declare that they have no competing interests. (Copyright: © Palmieri et al.)
Databáze:	MEDLINE
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