Development of multiparticulate systems based on natural polymers for morin controlled release.

Autor: Sales LS; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), School of Dentistry, R. Humaitá, 1680 - Centro, Araraquara, São Paulo 14801-903, Brazil. Electronic address: luciana.solera@unesp.br., Gimenes MDS; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), School of Dentistry, R. Humaitá, 1680 - Centro, Araraquara, São Paulo 14801-903, Brazil., Meneguin AB; Department of Drugs and Pharmaceuticals, São Paulo State University (Unesp), School of Pharmaceutical Sciences, Jaú, Km 1, CP 502, Araraquara, São Paulo 14800-903, Brazil., Barud HDS; Biopolymers and Biomaterials Laboratory (BioPolMat), University of Araraquara - UNIARA, 14801-340 Araraquara, SP, Brazil., Achcar JA; Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: achcar@fmrp.usp.br., Brighenti FL; Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), School of Dentistry, R. Humaitá, 1680 - Centro, Araraquara, São Paulo 14801-903, Brazil. Electronic address: f.brighenti@unesp.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Feb 15; Vol. 228, pp. 1-12. Date of Electronic Publication: 2022 Dec 18.
DOI: 10.1016/j.ijbiomac.2022.12.146
Abstrakt: This study aimed to develop a multiparticulate system based on sodium alginate/gellan gum polymers for morin controlled release using standardized spray-dryer parameters. A 2 4 experimental factorial design was used to standardize spray-dryer parameters. After standardization, three systems with three different proportions of the natural polymers (50:50, 25:75, 75:25; sodium alginate: gellan gum) with and without morin (control) were developed. The systems were characterized according to its morphology and physicochemical properties. Next, the systems were evaluated regarding antibiofilm and antimicrobial activity against Streptococcus mutans. The factorial design indicated the use of the following parameters: i) air flow rate: 1.0 m 3 /min; ii) outlet temperature: 120 °C; iii) natural polymers combination in different proportions; iiii) polymer concentration: 2 %. Scanning electron microscopy showed microparticles with spherical shape and rough surface. The samples released 99.86 % ± 9.36; 85.45 % ± 8.31; 86.87 % ± 3.83 of morin after 480 min. The systems containing morin significantly reduced S. mutans biofilm biomass, microbial viability and acidogenicity when compared to their respective controls. In conclusion, the spray-dryer parameters were standardized to the highest possible yield values and proved to be efficient for morin encapsulation and controlled release. Furthermore, these systems controlled important virulence factors of S. mutans biofilms.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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