Environmental exposure to non-steroidal anti-inflammatory drugs and potential contribution to eggshell thinning in birds.

Autor: de Solla SR; Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, 867 Lakeshore Road, Burlington, ON L7S 1A1, Canada. Electronic address: shane.desolla@ec.gc.ca., King LE; Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, 867 Lakeshore Road, Burlington, ON L7S 1A1, Canada., Gilroy ÈAM; Aquatic Contaminants Research Division, Environment and Climate Change Canada, 867 Lakeshore Road, Burlington, ON L7S 1A1, Canada.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2023 Jan; Vol. 171, pp. 107638. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1016/j.envint.2022.107638
Abstrakt: Abnormally thin eggshells can reduce avian reproductive success, and have caused rapid population declines. The best known examples of this phenomenon are the widespread population crashes in birds, mostly raptors, fish eating birds, and scavengers, caused by the pesticide DDT and its isomers in the 1960s. A variety of other chemicals have been reported to cause eggshell thinning. Non-steroidal anti-inflammatory drugs (NSAIDs), which are extensively and increasingly used in human and veterinary medicine, may be one particularly concerning group of chemicals that demonstrate an ability to impair eggshell development, based both on laboratory studies and on their known mechanism of action. In this review, we outline environmental and wildlife exposure to NSAIDs, describe the process of eggshell formation, and discuss pathways affected by NSAIDs. We list pharmaceuticals, including NSAIDs, and other compounds demonstrated to reduce eggshell thickness, and highlight their main mechanisms of action. Dosing studies empirically demonstrated that NSAIDs reduce eggshell thickness through cyclooxygenase inhibition, which suppresses prostaglandin synthesis and reduces the calcium available for the mineralization of eggshell. Using the US EPA's CompTox Chemicals Dashboard, we show that NSAIDs are predicted to strongly inhibit cyclooxygenases. NSAIDs have been observed both in the putative diet of scavenging birds, and we report examples of NSAIDs detected in eggs or tissues of wild and captive Old World vultures. We suggest that NSAIDs in the environment represent a hazard that could impair reproduction in wild birds.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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